Evaluating factors related to chronic pain after hysterectomy
Official title: Evaluation of Central Sensitization, Fear-Avoidance, and Pain-Pressure Threshold With Chronic Pain in Post-Hysterectomy Patients: A Collaborative Cohort Study (EPOCH - Enhancing Post-operative Outcomes in Chronic Pain After Hysterectomy)
Run by KK Women's and Children's Hospital · NCT04014829 · Data updated 2026-11-12
This study is trying to find out what factors might lead to chronic pain after a hysterectomy in women, by looking at things like anxiety and how they feel about pain before and after the surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 21 Years to 80 Years |
| Sex | Women only |
| Enrollment | 436 (estimated) |
| Sponsor | KK Women's and Children's Hospital Government |
| Locations | 1 site (Singapore) |
| Status | Recruiting |
| Started | July 23, 2019 |
| Main results expected | December 2027 |
| Study ends | December 2027 |
| Registry record updated | August 14, 2026 |
| Trial ID | NCT04014829 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 21 to 80 undergoing elective abdominal or laparoscopic hysterectomy for benign gynecological conditions.
✕Probably not a fit
Patients with a history of chronic pain syndrome or those undergoing vaginal hysterectomy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to identify clinically relevant factors associated with chronic post-hysterectomy pain (CPHP) by assessing central sensitization, fear-avoidance, and pain-pressure thresholds in patients undergoing elective hysterectomy for benign conditions. The study will recruit 236 participants at KK Hospital in Singapore and evaluate these risk factors preoperatively, with follow-up assessments at 4 and 6 months post-surgery. Additionally, the study will explore the relationship between heart rate variability, anxiety levels, and anticipated pain with postoperative outcomes.
Why it matters
Potential benefit: If successful, this study could lead to improved preoperative assessments and interventions to reduce the risk of chronic pain after hysterectomy.
How similar studies have gone: While the specific combination of factors being studied is novel, previous studies have indicated that central sensitization and fear-avoidance are relevant to chronic pain outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 21 to 80 years old * American Society of Anesthesiologists Physical Scale (ASA) I to III * Benign gynaecological indications for hysterectomy * Elective abdominal or laparoscopic hysterectomy Exclusion Criteria: * Vaginal hysterectomy * Uterine prolapse, endometriosis, malignant disease, or pelvic pain as main indication for surgery * History of drug dependence or recreational drug use * History of chronic pain syndrome * Current chronic daily treatment with corticosteroids, excluding inhaled steroids * Allergy to study drugs * Major heart surgery * Heart transplant * Pacemaker inserted * Baseline non-sinus cardiac rhythm
Where it's running
-
KK Women's and Children's Hospital
Singapore, Singapore Recruiting
Study contacts
- Principal investigator: Farida Ithnin, MBBS — KK Women's and Children's Hospital
- Study coordinator: Ban Leong Sng, MBBS
- Email: sng.ban.leong@singhealth.com.sg
- Phone: +65 6394 1077
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.