Evaluating eye movements and training for stroke patients
Eye-movement Dynamics During Free Viewing as a Biomarker for Assessment of Visuospatial Functions and for Closed-loop Rehabilitation in Stroke
This study tests whether tracking eye movements can help understand vision problems in stroke patients and if a new training program using sound can improve their visual skills.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | IRCCS San Camillo, Venezia, Italy Academic / other |
| Locations | 2 sites (Padova, PD and 1 other locations) |
| Trial ID | NCT06965673 on ClinicalTrials.gov |
What this trial studies
This study investigates the relationship between eye movements and visuospatial deficits in stroke patients, aiming to identify potential biomarkers through eye movement analysis during free viewing of natural scenes. It also explores the feasibility of a novel visual exploration training that utilizes auditory biofeedback to improve visuospatial skills. Participants will undergo neuropsychological assessments and neuroimaging to correlate eye movement characteristics with cognitive and functional outcomes. A subset of participants will receive the visual training alongside standard rehabilitation to assess its effectiveness compared to a control group.
Who should consider this trial
Good fit: Ideal candidates are individuals who have experienced a first unifocal ischemic or hemorrhagic stroke with specific visual and cognitive deficits.
Not a fit: Patients with a history of previous strokes or multifocal deficits may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance rehabilitation strategies for stroke patients suffering from visuospatial deficits.
How similar studies have performed: While the approach of using eye movements as biomarkers is gaining interest, this specific combination of interventions is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Vigilant * First unifocal ischemic or hemorragic stroke * Presence of maximum two lacunae, clinically silent, smaller than 15 mm. in the structural MRI * Evident symptoms in the visual, attentive, memory, motor or language domain supported by the radiological exam Exclusion Criteria: * Previous stroke history, visible at the radiological exam * Multifocal deficit * Incapacity to remain vigilant during the required assessments * Claustrophobia and/or metallic objects which could prevent MRI acquisition * Presence of other neurological, psychiatric or medical conditions which may undermine interpretation of behavioral and neuroimaging results
Where this trial is running
Padova, PD and 1 other locations
- Azienda Ospedaliera di Padova — Padova, Pd, Italy (Recruiting)
- IRCCS San Camillo — Venice-Lido, Ve, Italy (Recruiting)
Study contacts
- Principal investigator: Marco Zorzi — San Camillo IRCCS, Venice, Italy
- Study coordinator: Marco Zorzi
- Email: marco.zorzi@unipd.it
- Phone: +39 049 827 6618
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.