Evaluating eccDNAs as biomarkers for diagnosing biliary stricture

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the diagnostic capacity of cell-free extrachromosomal circular DNA (eccDNA) as biomarkers in patients with indeterminate biliary stricture. The study focuses on improving early diagnosis of malignant biliary strictures, which are often associated with poor prognosis due to late-stage presentation. Current diagnostic methods like brush cytology and biopsy during ERCP have low sensitivity, prompting the need for novel strategies. By analyzing eccDNA, the study seeks to enhance the accuracy of diagnosing conditions such as bile duct cancer and pancreatic cancer.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients is suspected indetermined biliary strictures
* Patients have the indication for ERCP

Exclusion Criteria:

* ERCP failed, or can not obtain bile
* Sever comorbidities
* Predicted overall survival less than 1 year because of other disease
* Patients who are unlikely to comply with the protocol, inability to return for subsequent visits

Where it's running

• Peking University Third Hospital
  Beijing, Beijing Municipality, China Recruiting
• Beijing Tsinghua Changgung Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Yonghui Huang — Peking University Third Hospital
• Study coordinator: Yonghui Huang, M.D
• Email: 13911765322@163.com
• Phone: +86-13911765322

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.