Evaluating D-dimer and Fibrinogen Levels for Diagnosing Aortic Dissection
Official title: Diagnostic Value of D-dimer/Fibrinogen Ratio in Patients With Acute Aortic Dissection
Run by Dr. Lutfi Kirdar Kartal Training and Research Hospital · NCT04251247 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing if measuring the D-dimer and fibrinogen levels can help doctors diagnose aortic dissection more accurately in patients who might have it.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 159 (estimated) |
| Sponsor | Dr. Lutfi Kirdar Kartal Training and Research Hospital Government |
| Locations | 2 sites (Istanbul and 1 other locations) |
| Trial ID | NCT04251247 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals diagnosed with acute aortic dissection, acute pulmonary embolism, or non-cardiac chest pain.
✕Probably not a fit
Patients with chest pain due to other etiologies unrelated to acute aortic dissection or acute pulmonary embolism may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the diagnostic value of the D-dimer/fibrinogen ratio in patients diagnosed with acute aortic dissection and acute pulmonary embolism. Given the rarity and life-threatening nature of acute aortic dissection, timely and accurate diagnosis is critical. The study aims to determine if the D-dimer/fibrinogen ratio can enhance diagnostic accuracy for these conditions. Participants will be assessed based on their D-dimer and fibrinogen levels to evaluate the effectiveness of this diagnostic approach.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic methods for acute aortic dissection, potentially saving lives through earlier detection.
How similar studies have gone: While the use of D-dimer in diagnosing aortic dissection has been explored, the specific approach of using the D-dimer/fibrinogen ratio is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of acute aortic dissection * Diagnosis of acute pulmonary embolism * Diagnosis of non-cardiac chest pain Exclusion Criteria: * Any etiology of chest pain other than acute aortic dissection, acute pulmonary embolism, or non-cardiac chest pain * Participants who do not give consent for enrollment
Where it's running
-
Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital
Istanbul, Turkey Recruiting -
Kartal Dr. Lutfi Kirdar Training and Research Hospital
Istanbul, Turkey Recruiting
Study contacts
- Study coordinator: Avni Uygar Seyhan, M.D.
- Email: uygarseyhan@gmail.com
- Phone: 902164583000
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
TRiP-cast score test in adults with acute lower-limb injuries requiring immobilization
This study tests whether the TRiP(cast) score can predict risk of blood clots in adults with acute lower-limb injuries treated as outpatients.
-
Prognostic value of the 2026 AHA/ACC PE classification in ED patients with acute PE
This study tests whether the 2026 AHA/ACC five-category PE classification helps predict 30-day major adverse pulmonary embolism events in adults with acute PE presenting to the ED.
-
Pregnancy-Related Aortic Dissection in China
This study looks at cases of aortic dissection that occur during pregnancy or shortly after, to understand outcomes for mothers and babies.
-
Right heart dysfunction in acute pulmonary embolism: can echocardiography help predict risk
This study tests whether transthoracic echocardiography can identify right ventricular dysfunction in adults with acute pulmonary embolism to help gauge risk.
-
Aspiration thrombectomy with the Symphony or Prodigy devices
This project will try the Symphony and Prodigy aspiration thrombectomy devices to remove arterial, venous, or pulmonary blood clots in adults.
-
PERC and YEARS approaches for diagnosing pulmonary embolism in the emergency department.
This project will test whether using the PERC score and the YEARS algorithm helps emergency doctors decide which adults need D-dimer blood tests or chest CT scans to diagnose pulmonary embolism.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.