Evaluating D-dimer and Fibrinogen Levels for Diagnosing Aortic Dissection
Diagnostic Value of D-dimer/Fibrinogen Ratio in Patients With Acute Aortic Dissection
This study is testing if measuring the D-dimer and fibrinogen levels can help doctors diagnose aortic dissection more accurately in patients who might have it.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 159 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Dr. Lutfi Kirdar Kartal Training and Research Hospital Government |
| Locations | 2 sites (Istanbul and 1 other locations) |
| Trial ID | NCT04251247 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the diagnostic value of the D-dimer/fibrinogen ratio in patients diagnosed with acute aortic dissection and acute pulmonary embolism. Given the rarity and life-threatening nature of acute aortic dissection, timely and accurate diagnosis is critical. The study aims to determine if the D-dimer/fibrinogen ratio can enhance diagnostic accuracy for these conditions. Participants will be assessed based on their D-dimer and fibrinogen levels to evaluate the effectiveness of this diagnostic approach.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with acute aortic dissection, acute pulmonary embolism, or non-cardiac chest pain.
Not a fit: Patients with chest pain due to other etiologies unrelated to acute aortic dissection or acute pulmonary embolism may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic methods for acute aortic dissection, potentially saving lives through earlier detection.
How similar studies have performed: While the use of D-dimer in diagnosing aortic dissection has been explored, the specific approach of using the D-dimer/fibrinogen ratio is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of acute aortic dissection * Diagnosis of acute pulmonary embolism * Diagnosis of non-cardiac chest pain Exclusion Criteria: * Any etiology of chest pain other than acute aortic dissection, acute pulmonary embolism, or non-cardiac chest pain * Participants who do not give consent for enrollment
Where this trial is running
Istanbul and 1 other locations
- Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital — Istanbul, Turkey (Recruiting)
- Kartal Dr. Lutfi Kirdar Training and Research Hospital — Istanbul, Turkey (Recruiting)
Study contacts
- Study coordinator: Avni Uygar Seyhan, M.D.
- Email: uygarseyhan@gmail.com
- Phone: 902164583000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.