Evaluating consciousness impairment in severe brain injuries using advanced imaging techniques
Evaluation of Consciousness Impairment in Severe TBI and Full-cycle Neuroregulation Based on Multimodal Imaging
First Affiliated Hospital Xi'an Jiaotong University · NCT06469827
This study is testing new imaging techniques to see if they can help doctors better understand and identify consciousness levels in patients with severe brain injuries.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | First Affiliated Hospital Xi'an Jiaotong University (other) |
| Locations | 1 site (Xi'an, Shaanxi) |
| Trial ID | NCT06469827 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess consciousness impairment in patients with severe traumatic brain injury (TBI) through multimodal imaging techniques. It focuses on understanding the relationship between EEG power spectrum analysis and behavioral assessments to improve early identification and functional evaluation of patients. The study seeks to address challenges in accurately recognizing consciousness levels and developing a comprehensive rehabilitation strategy for individuals with severe neurological conditions. By analyzing data from patients with a Glasgow Coma Scale score of 3-8, the research aims to enhance the management of TBI and improve patient outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with severe TBI who have a Glasgow Coma Scale score between 3 and 8 and have experienced loss of consciousness for more than 6 hours.
Not a fit: Patients with a history of substance abuse, previous traumatic brain injuries, or other significant neurological disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved assessment and rehabilitation strategies for patients with severe traumatic brain injury.
How similar studies have performed: While there have been studies focusing on TBI and consciousness assessment, this specific approach utilizing multimodal imaging for early identification and rehabilitation is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. GCS 3-8 points 2. Loss of consciousness greater than 6 hours or consciousness and coma greater than 6 hours within 24 hours after injury Exclusion Criteria: 1. Alcohol consumption, substance abuse during or within the previous 24 hours 2. Previous history of traumatic brain injury, MRI contraindication, penetrating brain injury, psychotropic substance use, spinal cord injury, positive neurological examination, multifunctional disorder 3. Previous history of traumatic brain injury, MRI contraindication, penetrating brain injury, psychotropic substance use, spinal cord injury, positive neurological examination, multifunctional disorder
Where this trial is running
Xi'an, Shaanxi
- The First Affiliated Hospital of Xi'an Jiaotong University — Xi'an, Shaanxi, China (RECRUITING)
Study contacts
- Study coordinator: Zhuonan Wang
- Email: wangzhuonan@xjtu.edu.cn
- Phone: 15332359525
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Traumatic Brain Injury, severe traumatic brain injury, multimodal imaging, brain injury recovery, neuroregulation, disorder of consciousness