Evaluating child development from different endometrial preparation methods in IVF/ICSI
Official title: Development of IVF/ICSI Children Born From Frozen Embryo Transfer Cycles With Different Endometrial Preparation Protocols: Follow-up of a Randomized Controlled Trial
Run by Mỹ Đức Hospital · NCT05502770 · Data updated 2026-11-12
This study is testing how different methods used to prepare the womb for frozen embryo transfers affect the long-term development of children born through IVF or ICSI.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 6 Months to 18 Months |
| Sex | All |
| Enrollment | 700 (estimated) |
| Sponsor | Mỹ Đức Hospital Academic / other |
| Locations | 1 site (Ho Chi Minh City) |
| Status | Recruiting |
| Started | August 12, 2022 |
| Main results expected | December 2025 |
| Study ends | December 2025 |
| Registry record updated | September 16, 2025 |
| Trial ID | NCT05502770 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include live IVF/ICSI babies born from frozen embryo transfers using the specified endometrial preparation methods.
✕Probably not a fit
Patients who have experienced the death of their baby before 24 months will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the long-term physical, mental, and motor development of children born from various endometrial preparation protocols used in frozen embryo transfer, specifically focusing on natural, modified natural, and artificial cycles. Building on findings from a previous randomized controlled trial, the study will utilize The Ages & Stages Questionnaires® to evaluate developmental outcomes up to 24 months after birth. The goal is to provide insights into the safety and efficacy of these preparation regimens on the health of IVF/ICSI children.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the safest endometrial preparation protocols, potentially leading to improved health outcomes for IVF/ICSI children.
How similar studies have gone: While this study builds on previous research, it focuses on a novel aspect of child development related to different endometrial preparation protocols, which has not been extensively studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All live IVF/ICSI babies born from frozen embryo transfer following the natural cycle, modified natural cycle, and artificial cycle from MONART study * Parents agree to participate in the study. Exclusion Criteria: * Babies died under or at 24 months
Where it's running
-
My Duc Hospital
Ho Chi Minh City, Vietnam Recruiting
Study contacts
- Study coordinator: Hieu LT Hoang
- Email: bshieu.hlt@gmail.com
- Phone: (+84) 969 166 318
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.