Evaluating blood biomarkers in advanced thyroid cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on adult patients diagnosed with advanced thyroid carcinomas, particularly those who are candidates for systemic therapy. It utilizes liquid biopsy techniques to analyze circulating DNA, RNA, and tumor cells from blood samples, aiming to create a molecular profile that can guide treatment decisions. By comparing these profiles to traditional genomic sequencing from tumor tissue, the study seeks to enhance patient selection for therapies and monitor treatment responses. The research highlights the potential of noninvasive methods to improve the management of thyroid cancer.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Signed written informed consent,
* Adult (≥18 years) male or female patients
* Histologic diagnosis of advanced thyroid carcinoma confirmed at centralized review,
* well-differentiated thyroid carcinomas, medullary thyroid carcinomas, anaplastic thyroid carcinomas, advanced, candidates for initiation of systemic medical therapy,
* Availability of biomolecular profiling performed by multigenic NGS panel on tumor tissue,
* Measurable disease by conventional imaging adopted in clinical practice (total body CT with mdc, CT-PET with FDG or F-DOPA).

Exclusion Criteria:

* Patients already receiving previous lines of systemic therapy,
* Patients not eligible for systemic therapy.

Where it's running

• IRCCS Azienda Ospedaliero universitaria Bologna
  Bologna, Italy Recruiting

Study contacts

• Study coordinator: Margherita Nannini
• Email: margherita.nannini@unibo.it
• Phone: +390512142207

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.