Evaluating a specific surgical technique for epilepsy treatment
Official title: Exploration and Evaluation of Amygdalo-Hippocampectomy According to Prof. Coubes' Technique: An Anatomical, Clinical, and Educational Approach
Run by University Hospital, Montpellier · NCT06915649 · Data updated 2026-11-12
This study is trying to see how well a specific surgical technique for epilepsy works in helping patients control their seizures and what factors might improve their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 3504 (estimated) |
| Sponsor | University Hospital, Montpellier Academic / other |
| Locations | 1 site (Montpellier, Hérault) |
| Status | Recruiting |
| Started | August 31, 2024 |
| Main results expected | September 2025 |
| Study ends | September 2025 |
| Registry record updated | April 8, 2025 |
| Trial ID | NCT06915649 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients who have undergone amygdalo-hippocampectomy using the specified surgical technique.
✕Probably not a fit
Patients who have not had the exact amygdalo-hippocampectomy procedure will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the long-term clinical outcomes and complications of amygdalo-hippocampectomy performed using a technique developed by Professor Coubes. It will analyze data from 234 patients treated over the past 30 years at the CHU de Montpellier, focusing on seizure outcomes, post-operative complications, and factors influencing recovery. The study seeks to identify variables associated with improved seizure control following surgery for conditions like hippocampal sclerosis and other temporal lobe diseases.
Why it matters
Potential benefit: If successful, this study could enhance surgical approaches for epilepsy treatment, leading to better seizure control and improved quality of life for patients.
How similar studies have gone: Other studies have shown varying success with similar surgical techniques, but this specific evaluation of Professor Coubes' method is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who had undergone an Amygdalo-Hippocampectomy according to the surgical procedure that we describe Exclusion Criteria: * Patients who did not have this exact procedure.
Where it's running
-
CHU de Montpellier
Montpellier, Hérault, France Recruiting
Study contacts
- Study coordinator: Pierre-Olivier MOSER, Medical Doctor
- Email: po-moser@chu-montpellier.fr
- Phone: +33 7 60 13 54 37
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Proton therapy for brain tumors
This study is testing whether proton therapy can be a better treatment option for patients with certain brain tumors by comparing it to traditional radiation methods to see if it can reduce harm to healthy tissues.
-
Islet re-transplantation after prior graft failure in adults with type 1 diabetes
This study looks at whether giving another islet transplant after a prior failed graft helps adults with type 1 diabetes who have severe swings in blood sugar.
-
Tissue models of systemic sclerosis using patient-derived iPSCs
Researchers will create iPSC lines from people with systemic sclerosis, their healthy relatives, and test them across several cell types to see how the disease affects tissues in the lab.
-
L-dopa treatment for a CTNNB1-related neurodevelopmental disorder in children
This study tests whether L-dopa can help children with a CTNNB1-related neurodevelopmental disorder who have dystonia.
-
Exploratory look at brain blood flow and metabolism before and after removing unruptured AVMs
This study tests brain perfusion and metabolism with PET imaging and neuropsychological tests in adults before and six months after surgical treatment for unruptured brain AVMs.
-
Immun4Cure Cohort of Autoimmune Diseases
A long-term, 500-person database and biobank is being built to study autoimmune diseases like RA, SLE, and scleroderma, plus healthy adults, using deep profiling and regular follow-ups over five years.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.