Clinical trial Recruiting at 1 site Interventional Ages 16 to 50

Evaluating a new technique for treating cartilage lesions

Official title: A Pilot Study to Evaluate the Functional Outcome of Nanofractures for the Treatment of Cartilage Lesions

Run by Ente Ospedaliero Cantonale, Bellinzona · NCT05660161 · Data updated 2026-11-12

This study is testing a new surgery technique called nanofractures to see if it helps younger patients with knee cartilage damage heal better than traditional methods.

Quick facts

Study typeInterventional
Ages16 Years to 50 Years
SexAll
Enrollment20 (estimated)
SponsorEnte Ospedaliero Cantonale, Bellinzona
Academic / other
Locations1 site (Lugano)
StatusRecruiting
StartedMarch 2, 2023
Main results expectedJanuary 2028
Study endsJanuary 2028
Registry record updatedSeptember 9, 2026
Trial IDNCT05660161 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients aged 16-50 with cartilage lesions of the knee who are scheduled for surgery.

Probably not a fit

Patients with significant knee instability, severe meniscus damage, or uncontrolled metabolic diseases may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the effectiveness of a novel treatment technique called nanofractures for patients with cartilage lesions in the knee. Nanofracturing involves creating smaller perforations in the bone to minimize damage while enhancing the healing process by increasing the availability of bone marrow-derived cells. The study will involve patients aged 16 to 50 who are scheduled for surgery to address their cartilage damage. By comparing outcomes from this technique to traditional methods, the study seeks to determine its efficacy in promoting cartilage repair.

Why it matters

Potential benefit: If successful, this technique could lead to improved healing of cartilage lesions and potentially reduce the risk of early-onset osteoarthritis.

How similar studies have gone: While the concept of nanofractures is relatively novel, similar techniques have shown promise in improving cartilage repair outcomes in preliminary studies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients with cartilage lesions of the knee scheduled for surgery
* Age 16-50
* BMI between 18.5 and 30 points
* Ability to give informed consent

Exclusion Criteria:

* Uncorrected knee instability
* Meniscectomy \> 50%
* Uncorrected knee misalignment
* Uncontrolled metabolic diseases
* Inability to give informed consent

Where it's running

  • Eoc
    Lugano, Switzerland
    Recruiting

Study contacts

  • Principal investigator: Luca Deabate, MD — Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
  • Study coordinator: Alessandro Sangiorgio, MD
  • Email: alessandro.sangiorgio@eoc.ch
  • Phone: +41 091 811 7029

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.