Evaluating a new technique for treating cartilage lesions
A Pilot Study to Evaluate the Functional Outcome of Nanofractures for the Treatment of Cartilage Lesions
This study is testing a new surgery technique called nanofractures to see if it helps younger patients with knee cartilage damage heal better than traditional methods.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 16 Years to 50 Years |
| Sex | All |
| Sponsor | Ente Ospedaliero Cantonale, Bellinzona Academic / other |
| Locations | 1 site (Lugano) |
| Trial ID | NCT05660161 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the effectiveness of a novel treatment technique called nanofractures for patients with cartilage lesions in the knee. Nanofracturing involves creating smaller perforations in the bone to minimize damage while enhancing the healing process by increasing the availability of bone marrow-derived cells. The study will involve patients aged 16 to 50 who are scheduled for surgery to address their cartilage damage. By comparing outcomes from this technique to traditional methods, the study seeks to determine its efficacy in promoting cartilage repair.
Who should consider this trial
Good fit: Ideal candidates are patients aged 16-50 with cartilage lesions of the knee who are scheduled for surgery.
Not a fit: Patients with significant knee instability, severe meniscus damage, or uncontrolled metabolic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this technique could lead to improved healing of cartilage lesions and potentially reduce the risk of early-onset osteoarthritis.
How similar studies have performed: While the concept of nanofractures is relatively novel, similar techniques have shown promise in improving cartilage repair outcomes in preliminary studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with cartilage lesions of the knee scheduled for surgery * Age 16-50 * BMI between 18.5 and 30 points * Ability to give informed consent Exclusion Criteria: * Uncorrected knee instability * Meniscectomy \> 50% * Uncorrected knee misalignment * Uncontrolled metabolic diseases * Inability to give informed consent
Where this trial is running
Lugano
- Eoc — Lugano, Switzerland (Recruiting)
Study contacts
- Principal investigator: Luca Deabate, MD — Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
- Study coordinator: Alessandro Sangiorgio, MD
- Email: alessandro.sangiorgio@eoc.ch
- Phone: +41 091 811 7029
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.