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Evaluating a new implant for lowering eye pressure in glaucoma patients

A Prospective, Multicenter Masked Clinical Trial to Evaluate the Safety and Effectiveness of the MINIject CS627 Implant in Subjects With Open Angle Glaucoma

Not applicable Interventional iSTAR Medical · NCT05024695

This study is testing a new implant to see if it can safely lower eye pressure in people with glaucoma better than the usual treatments.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment975 (estimated)
Ages46 Years and up
SexAll
SponsoriSTAR Medical Industry-sponsored
Locations37 sites (Glendale, Arizona and 36 other locations)
Trial IDNCT05024695 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to assess the safety and effectiveness of the MINIject™ implant developed by iSTAR Medical for reducing intraocular pressure (IOP) in individuals diagnosed with primary open-angle glaucoma. It is a prospective, multicenter, masked trial that involves multiple research sites. Participants will be monitored to determine how well the implant performs compared to standard treatments for managing glaucoma.

Who should consider this trial

Good fit: Ideal candidates for this study are males and females aged 46 and older with a diagnosis of primary open-angle glaucoma who are suitable for medical therapy, laser treatment, or glaucoma-filtering surgery.

Not a fit: Patients with angle closure, congenital, or secondary glaucoma, as well as those with significant visual disorders or intraocular inflammation, may not benefit from this study.

Why it matters

Potential benefit: If successful, this implant could provide a new, effective treatment option for patients with primary open-angle glaucoma, potentially improving their quality of life.

How similar studies have performed: Other studies have shown promise with similar minimally invasive glaucoma surgeries (MIGS), indicating that this approach may be effective.

Eligibility criteria

Show full inclusion / exclusion criteria 
Key Inclusion Criteria:

* Males and females, 46 years of age or older
* A diagnosis of primary open-angle glaucoma, who are candidates for medical therapy, laser treatment, or glaucoma-filtering surgery
* Pseudophakic with prior uncomplicated cataract surgery

Key Exclusion Criteria:

* Angle closure, congenital, or secondary glaucoma
* Diagnosed degenerative visual disorders
* Clinically significant intraocular inflammation or infection

Where this trial is running

Glendale, Arizona and 36 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions GlaucomaglaucomaMIGSprimary open angle glaucomasuprachoroidal spacesupraciliary space
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.