Evaluating a new imaging technique for stroke treatment
PeRfusiOn Post tHrombEcTomy (PROPHET) A Prospective Observational Cohort Study
Insel Gruppe AG, University Hospital Bern · NCT06691230
This study is testing a new imaging method to see if it can give doctors better information during stroke treatment to help them make more informed decisions.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 279 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Insel Gruppe AG, University Hospital Bern (other) |
| Locations | 2 sites (Basel and 1 other locations) |
| Trial ID | NCT06691230 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the diagnostic benefits of flat-panel detector computed tomography perfusion imaging (FDCTP) in patients undergoing mechanical thrombectomy for acute ischemic stroke. The study will involve multiple centers and will focus on patients who either received thrombectomy or had diagnostic angiography due to the intention of treatment. By analyzing FDCTP images obtained during or after the procedure, the study seeks to determine how often this new imaging technique reveals clinically relevant information that could influence treatment decisions. The primary goal is to establish whether FDCTP can provide insights that are not visible through traditional 2D digital subtraction angiography.
Who should consider this trial
Good fit: Ideal candidates are patients experiencing symptoms of acute ischemic stroke who are intended to undergo mechanical thrombectomy.
Not a fit: Patients who are not candidates for mechanical thrombectomy or those who cannot provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the decision-making process for stroke treatment, potentially leading to better patient outcomes.
How similar studies have performed: While the use of FDCTP is a novel approach in this context, similar imaging techniques have shown promise in other studies, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Informed consent as documented by a signature * The patients received mechanical thrombectomy or there was the intention to perform endovascular treatment, but only diagnostic angiography was performed. * Patients received FDCTP as clinically indicated by the treating physician. Exclusion Criteria: * Inability to give consent due to insufficient knowledge of the project language * Inability to follow the clinically indicated visit at 90 days after the index stroke (e.g. patients living abroad).
Where this trial is running
Basel and 1 other locations
- University Hospital Basel — Basel, Switzerland (NOT_YET_RECRUITING)
- University Hospital Bern — Bern, Switzerland (RECRUITING)
Study contacts
- Principal investigator: Johannes Kaesmacher, Prof. — University of Bern
- Study coordinator: Johannes Kaesmacher, Prof.
- Email: nctu@insel.ch
- Phone: +41 31 66 4 05 38
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Stroke, Acute, Ischemic, Acute ischemic stroke, Large-vessel occlusion, Endovascular mechanical thrombectomy, Flat-panel detector computed tomography perfusion imaging, Perfusion imaging