Evaluating a new imaging technique for stroke treatment
Official title: PeRfusiOn Post tHrombEcTomy (PROPHET) A Prospective Observational Cohort Study
Run by Insel Gruppe AG, University Hospital Bern · NCT06691230 · Data updated 2026-11-12
This study is testing a new imaging method to see if it can give doctors better information during stroke treatment to help them make more informed decisions.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 279 (estimated) |
| Sponsor | Insel Gruppe AG, University Hospital Bern Academic / other |
| Locations | 2 sites (Basel and 1 other locations) |
| Status | Recruiting |
| Started | November 1, 2024 |
| Main results expected | November 30, 2027 |
| Study ends | February 28, 2028 |
| Registry record updated | November 15, 2024 |
| Trial ID | NCT06691230 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients experiencing symptoms of acute ischemic stroke who are intended to undergo mechanical thrombectomy.
✕Probably not a fit
Patients who are not candidates for mechanical thrombectomy or those who cannot provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the diagnostic benefits of flat-panel detector computed tomography perfusion imaging (FDCTP) in patients undergoing mechanical thrombectomy for acute ischemic stroke. The study will involve multiple centers and will focus on patients who either received thrombectomy or had diagnostic angiography due to the intention of treatment. By analyzing FDCTP images obtained during or after the procedure, the study seeks to determine how often this new imaging technique reveals clinically relevant information that could influence treatment decisions. The primary goal is to establish whether FDCTP can provide insights that are not visible through traditional 2D digital subtraction angiography.
Why it matters
Potential benefit: If successful, this study could enhance the decision-making process for stroke treatment, potentially leading to better patient outcomes.
How similar studies have gone: While the use of FDCTP is a novel approach in this context, similar imaging techniques have shown promise in other studies, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Informed consent as documented by a signature * The patients received mechanical thrombectomy or there was the intention to perform endovascular treatment, but only diagnostic angiography was performed. * Patients received FDCTP as clinically indicated by the treating physician. Exclusion Criteria: * Inability to give consent due to insufficient knowledge of the project language * Inability to follow the clinically indicated visit at 90 days after the index stroke (e.g. patients living abroad).
Where it's running
-
University Hospital Bern
Bern, Switzerland Recruiting -
University Hospital Basel
Basel, Switzerland Not yet recruiting
Study contacts
- Principal investigator: Johannes Kaesmacher, Prof. — University of Bern
- Study coordinator: Johannes Kaesmacher, Prof.
- Email: nctu@insel.ch
- Phone: +41 31 66 4 05 38
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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-
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This trial tests whether giving a small amount of alteplase directly into the artery after a successful thrombectomy helps adults with acute ischemic stroke recover better.
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Intra-arterial Thrombolysis After Endovascular Thrombectomy in AIS
This trial tests whether giving intra-arterial thrombolysis with tenecteplase or alteplase after endovascular thrombectomy helps improve recovery in adults with acute ischemic stroke.
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This trial tests whether giving early endovascular treatment, instead of best medical care alone, helps adults with acute ischemic stroke caused by an isolated internal carotid artery occlusion recover better.
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IV tenecteplase given before clot removal for large-vessel ischemic stroke in the 4.5–24 hour window
This trial tests whether a single IV dose of tenecteplase given before clot removal helps people with large-vessel ischemic stroke who arrive 4.5–24 hours after they were last well.
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Intra-arterial alteplase after successful reperfusion for anterior circulation ischemic stroke
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.