Clinical trial Recruiting at 1 site Observational Ages 18 and up

Evaluating a new imaging technique for stroke treatment

Official title: PeRfusiOn Post tHrombEcTomy (PROPHET) A Prospective Observational Cohort Study

Run by Insel Gruppe AG, University Hospital Bern · NCT06691230 · Data updated 2026-11-12

This study is testing a new imaging method to see if it can give doctors better information during stroke treatment to help them make more informed decisions.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment279 (estimated)
SponsorInsel Gruppe AG, University Hospital Bern
Academic / other
Locations2 sites (Basel and 1 other locations)
StatusRecruiting
StartedNovember 1, 2024
Main results expectedNovember 30, 2027
Study endsFebruary 28, 2028
Registry record updatedNovember 15, 2024
Trial IDNCT06691230 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients experiencing symptoms of acute ischemic stroke who are intended to undergo mechanical thrombectomy.

Probably not a fit

Patients who are not candidates for mechanical thrombectomy or those who cannot provide informed consent may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the diagnostic benefits of flat-panel detector computed tomography perfusion imaging (FDCTP) in patients undergoing mechanical thrombectomy for acute ischemic stroke. The study will involve multiple centers and will focus on patients who either received thrombectomy or had diagnostic angiography due to the intention of treatment. By analyzing FDCTP images obtained during or after the procedure, the study seeks to determine how often this new imaging technique reveals clinically relevant information that could influence treatment decisions. The primary goal is to establish whether FDCTP can provide insights that are not visible through traditional 2D digital subtraction angiography.

Why it matters

Potential benefit: If successful, this study could enhance the decision-making process for stroke treatment, potentially leading to better patient outcomes.

How similar studies have gone: While the use of FDCTP is a novel approach in this context, similar imaging techniques have shown promise in other studies, suggesting potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Informed consent as documented by a signature
* The patients received mechanical thrombectomy or there was the intention to perform endovascular treatment, but only diagnostic angiography was performed.
* Patients received FDCTP as clinically indicated by the treating physician.

Exclusion Criteria:

* Inability to give consent due to insufficient knowledge of the project language
* Inability to follow the clinically indicated visit at 90 days after the index stroke (e.g. patients living abroad).

Where it's running

  • University Hospital Bern
    Bern, Switzerland
    Recruiting
  • University Hospital Basel
    Basel, Switzerland
    Not yet recruiting

Study contacts

  • Principal investigator: Johannes Kaesmacher, Prof. — University of Bern
  • Study coordinator: Johannes Kaesmacher, Prof.
  • Email: nctu@insel.ch
  • Phone: +41 31 66 4 05 38

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.