Evaluating a decision support system for preventing blood clots in brain injury patients

Evaluation of the SCALED (SCaling AcceptabLE cDs) Approach for the Implementation of Interoperable CDS for Venous Thromboembolism Prevention - CDS Data

Observational University of Minnesota · NCT05628207

This study is testing a new system to help doctors prevent blood clots in adults who have suffered a brain injury.

Quick facts

Study typeObservational
Enrollment15000 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Minnesota Academic / other
Locations1 site (Minneapolis, Minnesota)
Trial IDNCT05628207 on ClinicalTrials.gov

What this trial studies

This project aims to adapt an existing Clinical Decision Support (CDS) system to implement a venous thromboembolism (VTE) prevention guideline specifically for adult patients with traumatic brain injury (TBI). The study will involve seven institutions to scale, evaluate, and maintain this interoperable CDS system. By focusing on TBI patients, the project seeks to address a critical need in preventing VTE in trauma cases, leveraging previous experiences in guideline implementation.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 and older who are admitted to the hospital with a traumatic brain injury.

Not a fit: Patients who die within 24 hours of admission or those classified as 'comfort cares' during the first 72 hours, as well as those with mild TBI, may not benefit from this study.

Why it matters

Potential benefit: If successful, this could significantly reduce the incidence of venous thromboembolism in patients with traumatic brain injury.

How similar studies have performed: Other studies have shown success in implementing clinical decision support systems for VTE prevention, making this approach promising yet still focused on a specific patient population.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* age 18 and older
* admitted with a TBI

Exclusion Criteria:

* Patients who die within 24 hours of hospital admission and patients documented as "comfort cares" during the first 72 hours of hospitalization or with mild TBI will be excluded from final analysis.

Where this trial is running

Minneapolis, Minnesota

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Traumatic Brain InjuryVenous Thromboembolism
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.