Endovascular treatment for acute ischemic stroke with artery narrowing
Endovascular Treatment of Acute Ischemic Stroke With Underlying Intracranial Artery Stenosis: a Prospective, Multicentre Registry Study
This study is testing how well emergency endovascular treatments, like balloon dilation and stenting, work for patients with acute ischemic stroke caused by blocked arteries and narrowing in the brain.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 470 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Tianjin Huanhu Hospital Academic / other |
| Locations | 1 site (Tianjin, Tianjin) |
| Trial ID | NCT06260969 on ClinicalTrials.gov |
What this trial studies
This observational study aims to analyze the outcomes of patients with acute ischemic stroke caused by large vessel occlusion and underlying intracranial artery stenosis (ICAS) who receive emergency endovascular treatments. Conducted across 10 stroke centers in China from September 2022 to September 2025, the study will follow patients undergoing various endovascular interventions, including balloon dilation and stenting. The primary goal is to establish a cohort and evaluate the efficacy and safety of these treatments, as well as the neuroprotective effects of selective endovascular hypothermia. The findings will provide valuable clinical evidence to guide future interventional strategies for this patient population.
Who should consider this trial
Good fit: Ideal candidates include patients with acute ischemic stroke due to large vessel occlusion and underlying ICAS who meet specific clinical and imaging criteria.
Not a fit: Patients with hemorrhagic strokes, severe coagulation disorders, or those who cannot undergo mechanical thrombectomy are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve treatment outcomes for patients suffering from acute ischemic stroke due to large vessel occlusion and ICAS.
How similar studies have performed: While the approach of using endovascular treatments for acute ischemic stroke is established, the specific focus on ICAS and selective hypothermia is relatively novel and may provide new insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * CT scan to exclude intracranial haemorrhage；CT angiography (CTA), magnetic resonance angiography (MRA) or digital subtraction angiography showing occlusion of the distal intracranial carotid artery or the first segment of the middle cerebral artery；ELVO with a base ICAS of \> 70%；Mechanical thrombectomy within 6h after symptom onset in ischemic stroke；NIHSS≥6；receiving endovascular treatments；informed consent form signed by the patient or their legal representatives. Exclusion Criteria: * Hemorrhagic body, coagulation factor deficiency or oral anticoagulant therapy(INR \> 3.0)；Baseline platelet count \<50,000/µL；Baseline blood glucose \<50mg/dL or \>400mg/dL；Intractable hypertension(systolic blood pressure \>220 mmHg or diastolic blood pressure \>110 mmHg) that cannot be controlled by medication；Patients intubated without a NIHSS score assessed by a neurologist or emergency physician prior to intubation；Stroke attack with epilepsy affecting baseline NIHSS score；End-stage diseases leading to less than one year of expected survival for patients；Severe allergy to contrast media；Patients with renal insufficiency (blood creatinine ≥ 3 mg/dL)；Female patients who are pregnant or breastfeeding；The patient is participating in other drugs or device studies that may affect this study；Patient with cerebral vasculitis
Where this trial is running
Tianjin, Tianjin
- Tianjin Huanhu Hospital — Tianjin, Tianjin, China (Recruiting)
Study contacts
- Principal investigator: Ming Wei, doctorate — Tianjin Huanhu Hospital
- Study coordinator: Ming Wei, PhD
- Email: drweiming@163.com
- Phone: 13502182903
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.