How short aerobic workouts affect tumor cells in breast cancer survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional protocol compares the immediate biological effects of one session of moderate‑intensity versus high‑intensity continuous aerobic exercise on blood‑borne factors and tumor cell behavior. Premenopausal women who survived stage II–III triple‑negative breast cancer (3–9 months after completing treatment) and matched healthy control women will undergo cardiologist‑cleared exercise testing and supervised exercise sessions. Blood samples collected before and after exercise will be analyzed for myokine responses and applied to breast cancer cell lines to measure changes in tumor cell viability and signaling. The work will be performed at the Laboratory of Sports and Nutrition Research at Riga Stradins University.

Why it matters

Who can join: the full rules

Inclusion Criteria (intervention group):

* Reproductive age (premenopausal);
* Diagnosis of Stage II-III Triple-Negative Breast Cancer (TNBC) (negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2));
* Timeframe of 3 to 9 months after completion of surgery, adjuvant chemotherapy, radiation therapy, and/or immunotherapy;
* Physician-certified (cardiologist) physical fitness for exercise testing, supported by echocardiography (ECHO).

Inclusion Criteria (control group):

* Reproductive age (premenopausal);
* No current or prior diagnosis of any type of cancer;
* Matched by age, body constitution, and physical fitness to the breast cancer participant group.

Exclusion Criteria:

* Pregnancy;
* Autoimmune diseases (e.g., thyroiditis, inflammatory bowel disease, atopic dermatitis, etc.);
* Endocrine disorders (e.g., metabolic syndrome, diabetes);
* Cardiovascular diseases;
* Diagnosis of any other type of oncological disease;
* Any condition for which physical activity is contraindicated (e.g., asthma, COPD, spinal disc herniation, severe iron deficiency anemia).

Where it's running

• Laboratory of Sports and Nutrition Research
  Riga, Dzirciema Street 16, Latvia Recruiting

Study contacts

• Study coordinator: Dace Reihmane, PhD
• Email: Dace.Reihmane@rsu.lv
• Phone: +37126032249

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.