Elimination Diet Strategies and Histologic Remission in Children with EGID
Official title: Elimination Diet Strategies, Histologic Remission, and Clinical Follow-Up in Children With Eosinophilic Gastrointestinal Disorders: A Prospective Cohort Study
Run by Cukurova University · NCT07779772 · Data updated 2026-11-12
This observational study will see if elimination diets chosen by doctors for children ages 2–17 with eosinophilic gastrointestinal disorders can lead to symptom relief and histologic remission.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 2 Years to 18 Years |
| Sex | All |
| Enrollment | 34 (estimated) |
| Sponsor | Cukurova University Academic / other |
| Locations | 1 site (Adana, Sarıcam) |
| Status | Recruiting |
| Started | July 1, 2026 |
| Main results expected | March 1, 2028 |
| Study ends | September 1, 2028 |
| Registry record updated | August 21, 2026 |
| Trial ID | NCT07779772 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are children 2–17 years with an EGID undergoing endoscopy for clinical indications and without other confounding causes.
✕Probably not a fit
Patients whose EGID does not respond to diet or who cannot maintain elimination diets may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective cohort follows children with EGIDs to observe clinical symptoms, growth, and histology before and after an elimination diet chosen as part of routine care. Diet type (single to six-food eliminations) is determined by the treating physician with dietitian support, not by the study protocol. Endoscopy and biopsies, performed for clinical reasons, will be used to assess histologic response after about 8–12 weeks. Data on food reintroduction and disease recurrence will be collected to understand durability. The study does not assign a specific diet and relies on standard clinical practice.
Why it matters
Potential benefit: If successful, identifying dietary approaches associated with remission could guide personalized dietary management for children with EGIDs.
How similar studies have gone: Prior observations in dietary management for EGIDs suggest potential histologic and symptom improvements with elimination diets, but controlled data are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 2-17 years. * Presence of gastrointestinal symptoms such as abdominal pain, vomiting, diarrhea, hematemesis, or hematochezia. * Undergoing upper and/or lower gastrointestinal endoscopy for a clinical indication. * Histologic eosinophilic infiltration consistent with an eosinophilic gastrointestinal disorder. * Exclusion of other relevant causes of gastrointestinal eosinophilia. Exclusion Criteria: * Inflammatory bowel disease, parasitic infection, celiac disease, drug-associated enteropathy, hypereosinophilic syndrome, or other identified causes of gastrointestinal eosinophilia. * Known primary immunodeficiency. * Active malignancy. * Systemic rheumatologic disease.
Where it's running
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Cukurova University Balcali Hospital
Adana, Sarıcam, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Ali Islek, MD
- Email: aislek@cu.edu.tr
- Phone: 903223386060 (158)
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.