Electro-acupuncture for women with reduced ovarian function
Effect of Electro-acupuncture on Ovarian Function and Outcome of IVF-ET of Women With Diminished Ovarian Reserve：a Randomized Controlled Clinical Trial
This study tests if electro-acupuncture can help women with reduced ovarian function feel better and improve their chances of success with in vitro fertilization (IVF).
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 338 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | Female |
| Sponsor | Huazhong University of Science and Technology Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Wuhan, Hubei) |
| Trial ID | NCT04972877 on ClinicalTrials.gov |
What this trial studies
This trial investigates the effects of electro-acupuncture on women diagnosed with diminished ovarian reserve (DOR), a condition that can lead to reduced fertility. Participants will undergo 24 sessions of electro-acupuncture over a period of 2-3 months, with baseline measurements taken before and after treatment to assess changes in ovarian function and overall well-being. The study aims to determine if electro-acupuncture can improve outcomes for women undergoing in vitro fertilization (IVF) by enhancing ovarian function.
Who should consider this trial
Good fit: Ideal candidates are women under 40 years old with low ovarian reserve who are planning to undergo IVF.
Not a fit: Patients with certain reproductive system abnormalities or other significant endocrine diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could improve ovarian function and increase the chances of successful IVF outcomes for women with diminished ovarian reserve.
How similar studies have performed: Previous studies have shown promising results for acupuncture in improving ovarian function, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age \< 40, will undergo IVF-ET; 2. Low ovarian reserve: Antral follicle count (AFC)\<7, or AMH\<1.1ng/ml; or has a history of poor ovarian response: in the last hyper stimulation cycle, the number of retrieved oocytes\<3; 3. Spouse' semen examination is normal, or after semen prewash can reach the standard of common IVF or Intracytoplasmic Sperm Injection(ICSI). Exclusion Criteria: 1. Male with azoospermia; 2. Male/female's chromosome is abnormal; 3. Adenomyosis, uterine fibroids, endometrial polyps, scar uterine, reproductive system tuberculosis, oviduct effusion, pelvic lesions such as ovarian endometriosis cyst or tumor; 4. Female has other endocrine disease: thyroid diseases, hyperprolactinemia, insulin resistance, diabetes, adrenal diseases, etc. 5. Definitively diagnosed autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome; 6. Other pathogenesis that leads to recurrent miscarriage or agnogenic recurrent miscarriage; 7. A history of cancer and has received radiotherapy and chemotherapy; 8. Had acupuncture treatment in recent 3 months; 9. Unwilling to sign the informed consent of this study.
Where this trial is running
Wuhan, Hubei
- Department of Integrated Traditional Chinese and Western Medicine Tongji hospital of Huazhong University of Science and Technology — Wuhan, Hubei, China (Recruiting)
Study contacts
- Principal investigator: Dongmei Huang, doctor — Department of Integrated Traditional Chinese and Western Medicine Tongji hospital of Huazhong University of Science and Technology
- Study coordinator: Dongmei Huang, doctor
- Email: hdmjcr@qq.com
- Phone: 13971578190
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.