Tongue and gut bacteria patterns in women with diminished ovarian reserve

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares tongue-coating and intestinal microbiota between women diagnosed with diminished ovarian reserve (DOR) and healthy control women. Participants will provide tongue images, tongue coating samples, stool samples, and blood for ovarian reserve markers, and samples will be profiled by 16S rDNA sequencing with bioinformatics analysis. Researchers will correlate microbial features with serum AMH and FSH and compare shared taxa between tongue and gut to explore a tongue–gut microbial axis. The study aims to identify microbial markers or combinations that could serve as non-invasive indicators of DOR.

Why it matters

Who can join: the full rules

Inclusion Criteria Developed in accordance with:

The 13th Five-Year Plan textbook Obstetrics and Gynecology (9th Edition) by China National Health Commission The 14th Five-Year Plan National Key Publication Reproductive Endocrinology (2nd Edition) Expert Consensus on Clinical Diagnosis and Treatment of Diminished Ovarian Reserve (2022)

Inclusion Criteria:

* Female patients aged \>20 years.
* Diagnosis required meeting the essential criterion of AMH \<1.1 ng/mL plus at least one supportive criterion: FSH \>10 IU/L, FSH/LH ratio \>3.0, or AFC \<5-7 follicles (measured on menstrual days 2-3).
* Conscious with intact cognitive/linguistic functions to comply with study protocols.
* Approved by Ethics Committee of Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, with written informed consent obtained.

Exclusion Criteria:

* Female participants aged \<20 years.
* Women in menopause, pregnancy, or lactation period.
* Participants with comorbidities that may interfere with drug efficacy (e.g., severe chronic diseases).
* Severe primary disorders involving cardiovascular, hepatic, renal, hematopoietic systems, or psychiatric illnesses.
* Non-compliance with medication protocols during the study, or cases with undeterminable efficacy outcomes/incomplete data.
* Use of sex hormone therapy within the past 3 months.
* Diagnosis of reproductive system malignancies.
* Gastrointestinal disorders or abnormal liver function.
* Poor adherence to study protocols or lost to follow-up.

Where it's running

• Hangzhou TCM Hospital of Zhejiang Chinese Medical University
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Wenjun Xiao
• Email: Jenny_jun0829@163.com
• Phone: 0086-19858195019

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• G-CSF for DOR in women undergoing IVF

  This trial tests whether G-CSF shots can improve IVF outcomes for women with diminished ovarian reserve.

  Recruiting Phase 4 Center for Human Reproduction · New York, New York · NCT07871825

• Bushen Yiqi herbal formula plus DHEA for women with diminished ovarian reserve

  This trial will test whether adding the Bushen Yiqi herbal formula to DHEA helps women aged 20–40 with diminished ovarian reserve improve ovarian function and symptoms.

  Recruiting Phase 1/2 Jiangxi University of Traditional Chinese Medicine · Nanchang, Jiangxi · NCT07535983

• Vitamin C to improve IVF outcomes for women with diminished ovarian reserve

  This trial will test whether taking vitamin C during IVF improves pregnancy and live-birth chances for women with diminished ovarian reserve.

  Recruiting at 6 sites Peking University Third Hospital · Beijing, Beijing Municipality and 5 other locations · NCT06794047

• Using NMN to improve IVF outcomes in women with low ovarian reserve

  This study is testing if a supplement called NMN can help improve pregnancy success rates for women with low ovarian reserve who are going through IVF.

  Recruiting Peking University Third Hospital · Beijing, Beijing Municipality · NCT06426355

• Pulsatile FSH treatment for women with obesity to improve fertility

  This study is testing if a new way of giving hormone treatment can help women with obesity who are having trouble getting pregnant.

  Recruiting Phase 1 University of Colorado, Denver · Aurora, Colorado · NCT06414096

• Examining the link between ovarian function and serum biomarkers

  This study is trying to see how blood markers differ between healthy women and those with ovarian issues to better understand their connection.

  Recruiting Dongzhimen Hospital, Beijing · Beijing · NCT06096766

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.