Electrical stimulation for neuropathic and postoperative pain evaluation
Selective Activation of Unmyelinated Skin Nerve Fibres Using Slow Depolarising Transcutaneous Electrical Stimulation in Patients With Neuropathic Pain or Chronic Postoperative Pain
Swiss Paraplegic Research, Nottwil · NCT03037684
This study is testing if a special type of electrical stimulation can help people with nerve pain or pain from surgery feel better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 75 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Swiss Paraplegic Research, Nottwil (network) |
| Locations | 1 site (Nottwil) |
| Trial ID | NCT03037684 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the role of voltage-gated sodium channel NaV1.7 in neuropathic pain and chronic postoperative pain. It utilizes sinus-like electrical stimulation to assess pain responses in patients, particularly focusing on unmyelinated skin nociceptors. The study will characterize pain states in peripheral neuropathic pain and painful scars from postoperative conditions, employing techniques such as laser-evoked potentials and quantitative sensory testing. Additionally, pain-related questionnaires will be collected to gather comprehensive data on patient experiences.
Who should consider this trial
Good fit: Ideal candidates include individuals experiencing neuropathic pain or chronic postoperative pain.
Not a fit: Patients with severe psychiatric disorders or other neurological diseases unrelated to their pain diagnosis may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients suffering from neuropathic and chronic postoperative pain.
How similar studies have performed: While this approach is innovative, similar studies exploring the role of sodium channels in pain have shown promise, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Group (1) patients with neuropathic pain * Group (2) patients with chronic postoperative pain Exclusion Criteria (both Groups): * severe psychiatric disorder requiring hospitalisation in the past * any neurological disease other than the pain diagnosis
Where this trial is running
Nottwil
- Centre for Pain Medicine — Nottwil, Switzerland (RECRUITING)
Study contacts
- Study coordinator: Gunther Landmann, MD
- Email: gunther.landmann@paraplegie.ch
- Phone: +4141939
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Neuropathy, Peripheral, neuropathic pain, chronic postoperative pain