Elecoglipron vs. placebo in adults with chronic kidney disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a Phase III, randomized, double-blind study conducted at multiple centers to compare elecoglipron with placebo in adults with chronic kidney disease. Participants are on background SGLT2 inhibitors and standard care for CKD. The study includes people with CKD, with or without type 2 diabetes, and requires stable concomitant therapies. Primary outcomes focus on kidney-related measures and overall safety over the trial period. The trial is sponsored by AstraZeneca and includes several US sites.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults with confirmed CKD; UACR ≥30 mg/g and eGFR ≥20 mL/min/1.73 m² within specified ranges.
* On stable, patient maximum tolerated, labeled daily dose of ACEI or ARB for ≥4 weeks at least 28 days before screening.

Exclusion Criteria:

* BMI \<23 kg/m² at screening
* History of type 1 diabetes mellitus
* HbA1c ≥10% (86 mmol/mol) at screening
* Currently receiving, or anticipated to receive, therapeutic intervention for diabetic retinopathy and/or macular edema.
* Have had more than one episode of severe hypoglycemia within 180 days prior to screening, or hypoglycemia unawareness
* Acute coronary syndrome, major cardiac procedure, stroke, or TIA within 3 months prior to screening
* Clinically significant condition affecting the upper GI tract or chronic use of any medication that affects gastric motility or gastric emptying
* History of acute or chronic pancreatitis
* History/family history (first degree) of medullary thyroid cancer or MEN2

Where it's running

• Research Site
  Minneapolis, Minnesota, United States Recruiting
• Research Site
  Arlington, Texas, United States Recruiting
• Research Site
  South Salt Lake, Utah, United States Recruiting
• Research Site
  Gosford, Australia Recruiting
• Research Site
  Southport, Australia Recruiting
• Research Site
  Toronto, Ontario, Canada Recruiting

+665 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Study coordinator: AstraZeneca Clinical Study Information Center
• Email: information.center@astrazeneca.com
• Phone: 1-877-240-9479

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Observational look at how Kremezin works in adults with advanced chronic kidney disease

  This study tests whether Kremezin helps adults with advanced kidney disease when used as part of routine care, by tracking safety and kidney function over up to 48 weeks.

  Recruiting HK inno.N Corporation · Seoul · NCT07930169

• Kidney and Heart Health in Adults with Type 2 Diabetes and CKD Treated with Semaglutide in China

  This study tests whether semaglutide injections help kidney and heart health in adults with type 2 diabetes and chronic kidney disease.

  Recruiting Phase 4 Novo Nordisk A/S · Fuyang, Anhui and 25 other locations · NCT07900438

• High BMI and periodontitis in Thai adults under 60

  This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.

  Recruiting Mahidol University · Bangkok, Ratchathewi · NCT07880717

• Optimised Cardio-Renal Care for CKD and heart disease

  This study tests whether a specialised Cardio-Renal Clinic can improve heart and kidney health and quality of life for adults with chronic kidney disease and cardiovascular disease.

  Recruiting Odense University Hospital · Svendborg · NCT07835828

• NMR-based Risk Test and Digital Health Support for midlife adults in Eloisa

  This study tests whether an NMR metabolomics risk test can guide tailored digital health programs for midlife adults at risk of diabetes, heart disease, stroke, kidney disease, or fatty liver.

  Recruiting University of Eastern Finland · Savonlinna · NCT07820800

• Arterial stiffness in children and young people with CKD and hypertension

  This study will test whether arterial stiffness is higher in children and young people with chronic kidney disease and high blood pressure compared with their peers, using a one-time assessment and follow-up for those with high BP.

  Recruiting King's College London · London, Greater London · NCT07768865

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.