Clinical trial Recruiting at 1 site Phase 4 Interventional Ages 18 and up

Efficacy of continuous intercostal nerve block for patients with multiple rib fractures

Official title: The Efficacy of Continuous Intercostal Nerve Blocks in the Treatment of Patients With Multiple Rib Fractures

Run by University of Kentucky · NCT05642026 · Data updated 2026-11-12

This study is testing if a continuous intercostal nerve block can provide better pain relief for people with multiple rib fractures compared to standard pain management options.

Quick facts

PhasePhase 4
Study typeInterventional
Ages18 Years and up
SexAll
Enrollment180 (estimated)
SponsorUniversity of Kentucky
Academic / other
Locations1 site (Lexington, Kentucky)
StatusRecruiting
StartedSeptember 23, 2025
Main results expectedFebruary 1, 2027
Study endsFebruary 1, 2027
Registry record updatedOctober 29, 2026
Trial IDNCT05642026 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older with two or more rib fractures who consent to receive continuous nerve block therapy.

Probably not a fit

Patients with documented allergies to the study medication or those currently using an epidural catheter may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study evaluates the effectiveness of continuous intercostal nerve block (CINB) combined with medical therapy compared to standard medical care for patients with multiple rib fractures. It is a prospective, randomized, non-blinded trial that aims to assess pain management outcomes in patients admitted to the trauma service. Participants will receive either CINB with additional pain management or standard treatment involving nonsteroidal anti-inflammatory drugs and opioids. The goal is to determine if CINB provides superior pain relief and improves recovery.

Why it matters

Potential benefit: If successful, this approach could significantly enhance pain management for patients with multiple rib fractures, potentially reducing reliance on opioids.

How similar studies have gone: Similar studies have shown promising results with nerve block techniques for pain management, suggesting potential efficacy for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Subjects will be at least 18 years old
* Subjects will have 2 or more identified rib fractures
* Subjects will be willing to provide informed consent for procedure
* Subjects will be identified as appropriate for initiation of continuous nerve block therapy for treatment of rib fracture associated pain.

Exclusion Criteria:

* Documented allergy to study medication
* Epidural catheter use
* Prisoners
* Refusal of CINB therapy

Where it's running

  • University of Kentucky Medical Center
    Lexington, Kentucky, United States
    Recruiting

Study contacts

  • Principal investigator: Zachary Warriner, MD — University of Kentucky

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.