Effects of the MIND diet on cognitive function in adults with mild cognitive impairment
Effect of MIND Diet Intervention on Cognitive Function in Adults With Mild Cognitive Impairment
This study is testing if following the MIND diet for a year can help improve thinking and memory in adults over 50 who have mild cognitive impairment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 240 (estimated) |
| Ages | 60 Years to 80 Years |
| Sex | All |
| Sponsor | Zhejiang University Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT05975723 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of a 1-year cluster-randomized controlled intervention using the MIND diet on cognitive function in 240 adults aged 50 and above with mild cognitive impairment (MCI). Participants will be randomly assigned to either a MIND diet intervention group or a control group, with the diet focusing on brain-healthy foods while limiting unhealthy options. The study aims to assess both cognitive and biological outcomes resulting from the dietary changes over the intervention period.
Who should consider this trial
Good fit: Ideal candidates are adults aged 50 and above who are at risk of cognitive decline but do not have dementia.
Not a fit: Patients with diagnosed dementia, severe chronic diseases, or significant food allergies may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could enhance cognitive function and potentially delay the progression of cognitive decline in older adults with MCI.
How similar studies have performed: Previous studies have shown promising results with dietary interventions aimed at improving cognitive function, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * At risk of cognitive decline: cognitive performance at the mean level or slightly lower than expected for age with no dementia (AD8\>=3 and/or 5-min MoCA \< 11) * Free of physical disabilities that preclude participation in the study * Willing to complete all study-related activities for 24 months * Willing to be randomized to either intervention group Exclusion Criteria: * Allergic to more than one type of food (nuts, berries, olive oil, or fish) * Diagnosed of dementia, severe diabetes mellitus, cardiovascular disease, cancer, thyroid disease, kidney disease, or liver disease * Diagnosed of major depression or other neuropsychological diseases * Severe loss of vision, hearing or communicative ability * Substance abuse within 6 months or heavy alcohol consumption (\> 2 drinks/day for women; \> 3 drinks/day for men).
Where this trial is running
Hangzhou, Zhejiang
- Zhejiang University School of Medicine — Hangzhou, Zhejiang, China (Recruiting)
Study contacts
- Study coordinator: Changzheng Yuan, ScD
- Email: chy478@zju.edu.cn
- Phone: 86-17326860291
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.