Effects of TCAV and Volume Control Ventilation on Lung Health in ARDS Patients
Effects of Time-controlled Adaptive Ventilation (TCAV) and Volume Control Ventilation (VCV) on the Distribution of Aerated Lung Parenchyma in Patients With Acute Respiratory Distress Syndrome (ARDS): a Pilot Study
This study tests whether a new breathing method called Time-Controlled Adaptative Ventilation can help improve lung health in patients with Acute Respiratory Distress Syndrome compared to a standard method.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 33 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Central Hospital, Nancy, France Academic / other |
| Locations | 1 site (Nancy) |
| Trial ID | NCT05874973 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the impact of Time-Controlled Adaptative Ventilation (TCAV) compared to Volume-Controlled Ventilation (VCV) on lung aeration in patients suffering from Acute Respiratory Distress Syndrome (ARDS). The study aims to evaluate how these ventilation strategies affect lung function and oxygenation, utilizing thoracic CT scans to assess lung recruitment. Patients will be monitored for improvements in their respiratory status following the application of these ventilation techniques.
Who should consider this trial
Good fit: Ideal candidates for this study are patients diagnosed with ARDS who have been on invasive ventilation for no longer than 72 hours and require a diagnostic thoracic CT scan.
Not a fit: Patients with severe COPD, prolonged ARDS, or those experiencing severe hemodynamic instability may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved ventilation strategies that enhance lung function and reduce mortality in ARDS patients.
How similar studies have performed: Previous studies have shown promising results with TCAV in improving oxygenation and lung function, indicating that this approach may be beneficial.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ARDS according to the Berlin definition * invasive ventilation for no longer than 72 hours * patient requiring a diagnostic thoracic CT scan * consent of a family member or the person of trust * social security affiliation Exclusion Criteria: * Use of iodinated contrast media injection before CT acquisitions * ARDS criteria present during 72 hours or more * Severe COPD * Pneumothorax or other barotrauma-related complication * Right ventricular failure other than acute cor pulmonale * Absence of sedative agents and neuromuscular blockade * Severe hemodynamic instability (norepinephrine \> 0.5 µg/kg/min) * VA-ECMO assistance * Pregnancy * Absence of the capacity to give consent before admission to the ICU
Where this trial is running
Nancy
- Chru — Nancy, France (Recruiting)
Study contacts
- Principal investigator: Benjamin Pequignot — CHRU Nancy
- Study coordinator: Benjamin Pequignot, MD
- Email: b.pequignot@chru-nancy.fr
- Phone: +33383153851
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.