Effects of resistance training on muscle loss in older heart failure patients
Effects of Resistance Training on Sarcopenia in Older Patients With Chronic Heart Failure: A Randomized Controlled Trial
NA · University of Medicine and Pharmacy at Ho Chi Minh City · NCT06785168
This study tests if an eight-week strength training program can help older heart failure patients keep their muscles strong and improve their physical abilities.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 146 (estimated) |
| Ages | 60 Years and up |
| Sex | All |
| Sponsor | University of Medicine and Pharmacy at Ho Chi Minh City (other) |
| Locations | 2 sites (Ho Chi Minh City and 1 other locations) |
| Trial ID | NCT06785168 on ClinicalTrials.gov |
What this trial studies
This study evaluates the impact of an eight-week machine-based resistance training program on managing sarcopenia in older outpatients with chronic heart failure. Participants will be randomly assigned to either the resistance training group or a usual care group. Key outcomes will be assessed after the intervention, including handgrip strength, gait speed, and performance on the five-times sit-to-stand test to measure improvements in muscle strength and physical performance.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 60 and older diagnosed with sarcopenia and chronic heart failure.
Not a fit: Patients with unstable heart conditions or contraindications for exercise testing will not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could enhance muscle strength and physical function in older patients with heart failure, potentially improving their quality of life.
How similar studies have performed: Previous studies have shown positive outcomes with resistance training in similar populations, suggesting a promising approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged ≥ 60 years old * Meet the diagnostic criteria of 2019 AWGS2 sarcopenia, can be diagnosed once meeting (1) + (2) or (1) + (3) or (1) + (2) + (3): (1) Appendicular skeletal muscle mass (ASM): dual-energy X-ray absorptiometry (DXA) (male \<7.0 kg/m², female \<5.7 kg/m²). (2) Muscle strength: handgrip strength (male \<28.0 kg, female \<18.0 kg). (3) Physical performance: 6-meter walking speed \<1.0 m/s. * Meet the diagnostic criteria of heart failure following ESC 2021. * Clearly understand the content and purpose of the study and sign the informed consent form. Exclusion Criteria: There are contraindications for Exercise Testing in patients with stable heart failure according to ACSM 2022: * Early stage after acute coronary syndrome (within the first 2 days) * Unstable coronary artery disease * Decompensated heart failure * Acute venous thrombosis or recent arterial embolism (pulmonary or systemic) * Acute myocarditis, pericarditis, endocarditis * Aortic dissection of the valve * Severe symptomatic aortic stenosis * Acute systemic disease or fever * Uncontrolled or life-threatening atrial or ventricular arrhythmias (including new-onset atrial fibrillation or flutter) * Uncontrolled tachycardia (resting heart rate \> 120 beats per minute) * Third-degree AV block * Uncontrolled diabetes * Symptomatic orthostatic hypotension (\> 20 mmHg) * Gradually increasing fatigue during exercise or dyspnea at rest or with exertion within the past 3-5 days * Significant myocardial ischemia at low workloads \< 2 METs or 50W * Relative contraindications according to ACSM 2022: * Weight gain ≥ 1.8 kg in the past 1-3 days * Simultaneous use of continuous or intermittent Dobutamine * Decrease in blood pressure with exercise * NYHA IV heart failure * Complex ventricular arrhythmias at rest or with exertion * Resting heart rate ≥ 100 bpm when lying down * Comorbidities that limit exercise * Severe obstructive hypertrophic cardiomyopathy * Have participated in a cardiovascular rehabilitation program within the last 6 months * Do not agree to participate in the study
Where this trial is running
Ho Chi Minh City and 1 other locations
- Military Hospital 175 — Ho Chi Minh City, Vietnam (RECRUITING)
- University of Medicine and Pharmacy at Ho Chi Minh City — Ho Chi Minh City, Vietnam (RECRUITING)
Study contacts
- Study coordinator: Nguyen Dang P Kieu, M.D.
- Email: ndpkieu.ncs24@ump.edu.vn
- Phone: (+84)984701516
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Sarcopenia in Elderly, Chronic Heart Failure, sarcopenia, chronic heart failure, machine-based resistance training, age over 60, outpatient