Effects of nitrate-rich vegetables on gum disease and oral health
Effect of Nitrate-rich Vegetable Intake on Inflammatory Molecule Levels, Nitrate-reducing Capacity and Oral Microbiota Composition in Patients With Periodontitis
This study is testing if eating nitrate-rich vegetables can help people with gum disease improve their oral health and recovery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 30 Years to 65 Years |
| Sex | All |
| Sponsor | University of Guadalajara Academic / other |
| Locations | 1 site (Guadalajara, Jalisco) |
| Trial ID | NCT05232331 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the impact of consuming nitrate-rich vegetables, such as green leafy vegetables and beets, on patients with periodontitis. The study aims to evaluate how these vegetables affect inflammatory molecules in saliva, the capacity of oral bacteria to reduce nitrates, and the overall composition of the oral microbiota. By incorporating these vegetables into the diet of patients undergoing nonsurgical periodontal treatment, the researchers hope to enhance recovery and prevent relapse of the disease. The trial will involve 60 participants who meet specific eligibility criteria.
Who should consider this trial
Good fit: Ideal candidates are men and women aged 30 to 65 who are undergoing nonsurgical periodontal treatment and meet specific clinical criteria.
Not a fit: Patients with certain medical conditions, such as autoimmune diseases or those with a high risk of infection, may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could improve oral health outcomes and reduce the recurrence of periodontitis in patients.
How similar studies have performed: While the specific approach of using nitrate-rich vegetables is novel, previous studies have indicated that dietary modifications can positively influence oral health.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and/or women from 30 to 65 years old * Voluntary participation and signing the written informed consent * Not receiving nutritional treatment at the time of uptake * Availability to attend all scheduled visits * Have an indication to receive nonsurgical periodontal treatment (NSPT) * Interdental clinical insertion loss ≥3mm and ≥5mm in the buccal or oral area of two or more non-adjacent teeth * Detectable depths ≥ 5mm in two or more teeth * Radiographic evidence of periodontal bone loss Exclusion Criteria: * Trauma-Induced Gingival Recessions * Cervical caries * History of bleeding diathesis * Pregnant or nursing women * BMI \<18.5 kg / m2 * History of any of the following self-reported diseases: type 2 diabetes mellitus, high blood pressure, kidney or liver disease, inflammatory bowel diseases, autoimmune diseases and/ or use of medications to control these diseases. * Having or presenting a high risk of infection by tuberculosis, hepatitis B or Human Immunodeficiency Virus (HIV) * Use of antibiotics (including antibiotic oral rinse) 6 months prior to or during the study * Having received specialized periodontal treatment in the previous 6 months. * Smoking habit * Require an interpreter or not understand Spanish to attend or provide written material.
Where this trial is running
Guadalajara, Jalisco
- Integral Dental Clinics CUCS UDG — Guadalajara, Jalisco, Mexico (Recruiting)
Study contacts
- Principal investigator: Lucrecia Carrera, PhD — University of Guadalajara
- Study coordinator: Lucrecia Carrera, PhD
- Email: lucrecia.carrera@academicos.udg.mx
- Phone: +523310585200
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.