Effects of Morning vs Evening Exercise on Glucose Levels in Adults with Prediabetes
Examining the Effects of Morning and Evening Exercise on Glucose Regulation in Adults With Prediabetes
This study tests whether exercising in the morning or evening can help adults with prediabetes manage their blood sugar levels and improve their overall health.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 20 Years to 40 Years |
| Sex | All |
| Sponsor | University of Colorado, Denver Academic / other |
| Locations | 1 site (Aurora, Colorado) |
| Trial ID | NCT06292000 on ClinicalTrials.gov |
What this trial studies
This study investigates how exercising in the morning compared to the evening influences glucose metabolism, sleep quality, and overall activity levels in adults with prediabetes. Participants will undergo a series of screenings to determine eligibility, followed by a randomized crossover design where they will experience both morning and evening exercise conditions, separated by a baseline period of no exercise. Each exercise condition will last for three consecutive days, and participants will follow a controlled diet during the study. The goal is to better understand the optimal timing of exercise for improving metabolic health.
Who should consider this trial
Good fit: Ideal candidates are biologically female adults aged 20-40 with a BMI between 30.0 and 40.0 kg/m2 who are physically inactive and have prediabetes.
Not a fit: Patients with a history of cardiovascular disease, diabetes, or those currently on medications affecting insulin sensitivity may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the best times for exercise to enhance glucose regulation and overall health in individuals with prediabetes.
How similar studies have performed: While studies on exercise timing and glucose regulation exist, this specific comparison of morning versus evening exercise in prediabetic individuals is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 20-40 years. * Biologically female participants with regular menstruation * Body mass index (BMI) ≥ 30.0 to ≤ 40.0 kg/m2 * Prediabetes as defined by the American Diabetes Association (HgbA1c ≥ 5.7% to \< 6.5% or fasting glucose ≥ 100 to \< 126 mg/dL) * Physically inactive (\< 100 min/wk of regular exercise) * No contraindications to exercise or limitations on ability to be physically active * Weight stable (weight change \< 5kg in past 3 months) * Not currently pregnant or lactating, not pregnant within the past 6 months or planning to become pregnant in the next 6 months. Exclusion Criteria: * History or symptoms suggestive of cardiovascular disease or congestive heart failure * Diastolic blood pressure \> 100 mmHg, systolic blood pressure \> 160 mmHg, or resting heart rate \> 100 bpm * History of type 1 or type 2 DM (or fasting glucose ≥126 mg/dL or Hemoglobin A1C ≥6.5% on screening labs) * Current use of medications that effect SI (oral steroids, metformin, GLP1 receptor agonists, etc). * Chronic kidney disease (CKD, stage 4 or higher) * TSH, electrolytes, hematocrit, white blood cell count, or platelets significantly outside the normal reference range on screening labs * Triglycerides \> 400 or LDL \> 200 on screening labs * Clinically significant abnormality on resting ECG, presence, or history of any other metabolic or chronic health problems which would affect appetite, food intake, energy metabolism, or ability to participate in exercise, * History of obstructive sleep apnea, primary insomnia, night-time shiftwork, rotating work, or other atypical sleep patterns. * Current or recent (within 1 month) zero or very low carbohydrate diet (\< 10% daily calories from carbohydrates).
Where this trial is running
Aurora, Colorado
- University of Colorado — Aurora, Colorado, United States (Recruiting)
Study contacts
- Study coordinator: Rebecca Rosenberg, DO
- Email: rebecca.rosenberg@cuanschutz.edu
- Phone: 5034427062
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.