Effects of Metformin and Genetic Factors on Women with PCOS
Official title: Metabolic Responses of Metformin and Genetic Polymorphisms (rs628031 and rs2282143) of Solute Carrier Family 22 Member 1 Gene in Polycystic Ovary Syndrome
Run by Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh · NCT05680805 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing how well Metformin works for women with PCOS and whether their genetic makeup affects the treatment's success.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 35 Years |
| Sex | Women only |
| Enrollment | 100 (estimated) |
| Sponsor | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Academic / other |
| Locations | 1 site (Dhaka) |
| Trial ID | NCT05680805 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are newly diagnosed women aged 18 to 35 with Polycystic Ovary Syndrome.
✕Probably not a fit
Patients with other endocrine disorders, those planning to conceive soon, or those with diabetes or significant renal or liver disease may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates how genetic variations in the SLC22A1 gene affect the metabolic responses of women with Polycystic Ovary Syndrome (PCOS) to Metformin treatment. Conducted at Bangabandhu Sheikh Mujib Medical University, the study will enroll at least 100 women aged 18 to 35 diagnosed with PCOS. Participants will undergo a 24-week Metformin therapy, with assessments of metabolic profiles and genetic testing to categorize them based on specific gene polymorphisms. The study aims to determine both the efficacy of Metformin and the influence of genetic factors on treatment outcomes.
Why it matters
Potential benefit: If successful, this study could lead to personalized treatment strategies for women with PCOS, improving their metabolic health.
How similar studies have gone: While studies on Metformin's effects in PCOS are common, the specific focus on genetic polymorphisms in this context is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * • Newly diagnosed women of reproductive age (18 - 35 years) PCOS patients Exclusion Criteria: * • Patients having known similar endocrine disorders (hypothyroidism, hyperprolactinemia, androgen producing tumor, congenital adrenal hyperplasia, etc) * Planning to conceive within next six months, pregnant/ lactating mother * Patients with known diabetes mellitus, ischemic heart disease, chronic liver (serum ALT \>2 × upper limit of normal) and renal disease (eGFR \<60 ml/minute/1.73 m2 body surface area) * Patients taking oral contraceptive, steroid or drugs affecting insulin resistance (metformin, pioglitazone)
Where it's running
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Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University
Dhaka, Bangladesh Recruiting
Study contacts
- Principal investigator: Muhammad A Hasanat, MPhil, MD — Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
- Study coordinator: Muhammad A Hasanat, MPhil, MD
- Email: aryansowgat@gmail.com
- Phone: +88 01711-670735
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Precision acupuncture and lifestyle for PCOS
This trial tests whether a precision acupuncture approach combined with a personalized lifestyle plan helps improve insulin resistance in people with PCOS compared with conventional acupuncture and standard lifestyle changes.
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Orlistat for metabolic and hormonal features in women with PCOS
This trial tests whether adding orlistat to lifestyle advice helps improve metabolic and hormonal aspects in women with PCOS compared to lifestyle advice alone.
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Physical activity program for women with PCOS and fatty pancreas plus subclinical hypothyroidism
A program of exercise is being tested to see if it helps women with PCOS who also have fatty pancreas and subclinical hypothyroidism, compared to usual care.
-
Glucose monitoring in women with polycystic ovary syndrome
This project will use continuous glucose monitors to see if daily glucose patterns differ among adult women with different PCOS phenotypes.
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Adding regular exercise to a low‑calorie diet and metformin for women with PCOS and asthma
This study will test whether adding regular treadmill walking to a low‑calorie diet and daily metformin helps women who have both PCOS and asthma.
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Identifying insulin-resistant PCOS with LMNA-related lipodystrophy in young women
We’re testing whether women with a genetic insulin resistance and lipodystrophy differ from women with PCOS by age and BMI matching.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.