Effects of ketone supplements on exercise metabolism
The Effect of Acute Ketone Monoester Supplementation on Glucose Oxidation During Exercise Performed With High Rates of Carbohydrate Ingestion in Trained Cyclists
This study is testing if taking a ketone supplement before and during exercise helps endurance-trained adults use carbohydrates more effectively while they work out.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 27 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | Maastricht University Medical Center Academic / other |
| Locations | 1 site (Maastricht, Limburg) |
| Trial ID | NCT06746805 on ClinicalTrials.gov |
What this trial studies
This study investigates how exogenous ketone body supplementation influences carbohydrate metabolism during exercise. In a randomized, crossover, and double-blind design, 20 endurance-trained adults aged 18-50 will consume carbohydrates with either a ketone monoester supplement or a flavor-matched placebo before and during a 3-hour exercise session. The primary goal is to compare carbohydrate oxidation rates during exercise between the two conditions.
Who should consider this trial
Good fit: Ideal candidates are endurance-trained males and females aged 18-50 with a high VO2peak.
Not a fit: Patients with chronic medical conditions, musculoskeletal disorders, or those on carbohydrate-restrictive diets may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance athletic performance and recovery by optimizing energy metabolism during exercise.
How similar studies have performed: While the effects of ketone supplementation have been explored, this specific approach focusing on carbohydrate oxidation during exercise is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-50 years of age * Trained cyclist/triathlete (VO2peak \> 55 ml/kg/min for males and \>48 ml/mg/min for females) * Healthy as per medical history and investigator's/physician's judgement * Having given written informed consent Exclusion Criteria: * Use of medication that could impact study outcomes and/or interfere with the expected mechanism of action of ketone supplements (e.g. Chronic use of gastric acid suppressing medication, statins, corticosteroids) * Smoking * Diagnosed acute or chronic medical conditions that, in the opinion of the investigator, could impact study outcomes (e.g. Diabetes mellitus) * Diagnosed musculoskeletal disorders * Adhering to a carbohydrate restrictive diet * Participation in another study at the same time * Blood donation in the 2 months before the first experimental trial * Plasma donation in the 2 weeks before the first experimental trial * Males: VO2peak \<55 ml/min/kg body mass * Females: VO2peak \<48 ml/min/kg body mass * Females: pregnancy
Where this trial is running
Maastricht, Limburg
- Maastricht University Medical Center+ — Maastricht, Limburg, Netherlands (Recruiting)
Study contacts
- Study coordinator: Luc van Loon, PhD
- Email: l.vanloon@maastrichtuniversity.nl
- Phone: 0031 43 388 1743
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.