Effects of Ketamine and Etomidate on Long-Term Outcomes After Intubation
Effect of Ketamine and Etomidate During Rapid Sequence Intubation on Long- Term Outcomes (Long-Term Outcomes of the RSI Trial)
This study is trying to see if using ketamine or etomidate during intubation affects the long-term mental health and recovery of patients, especially in relation to PTSD symptoms.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1756 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Vanderbilt University Medical Center Academic / other |
| Locations | 1 site (Nashville, Tennessee) |
| Trial ID | NCT06179485 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the long-term outcomes of patients who received ketamine or etomidate during rapid sequence intubation (RSI) in the emergency department or ICU. It focuses on the prevalence of post-traumatic stress disorder (PTSD) symptoms in patients who have undergone intubation, as many experience distressing memories and psychological effects following the procedure. By collecting data from participants enrolled in a previous RSI trial, the study seeks to understand the impact of these medications on PTSD and overall recovery. The findings could inform future practices in managing patients undergoing critical interventions.
Who should consider this trial
Good fit: Ideal candidates are adults who were enrolled in the previous RSI trial and underwent intubation.
Not a fit: Patients who were aphasic, non-verbal, non-English speaking, or deaf prior to intubation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for preventing PTSD in patients who undergo intubation.
How similar studies have performed: Other studies have indicated that interventions during intubation can influence long-term psychological outcomes, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Enrolled in RSI trial (NCT05277896) Exclusion Criteria: * Aphasic or non-verbal prior to tracheal intubation * Cannot follow commands prior to tracheal intubation * Non-English speaking * Deaf
Where this trial is running
Nashville, Tennessee
- Vanderbilt University Medical Center — Nashville, Tennessee, United States (Recruiting)
Study contacts
- Study coordinator: Jonathan D Casey, MD, MSc
- Email: jonathan.d.casey@vumc.org
- Phone: 615-208-6139
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.