Effects of Inspiratory Muscle Training and PEP on ventilated restrictive lung disease patients
Official title: Effects of Inspiratory Muscle Training and Positive Expiratory Pressure on Mechanically Ventilated Restrictive Lung Disease Patients
Run by Foundation University Islamabad · NCT07867730 · Data updated 2026-11-12
This study tests whether inspiratory muscle training and positive expiratory pressure devices help strengthen breathing muscles and improve lung function in people with restrictive lung diseases who are on mechanical ventilation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Foundation University Islamabad Academic / other |
| Locations | 3 sites (Islamabad and 2 other locations) |
| Status | Recruiting |
| Started | December 1, 2025 |
| Main results expected | January 31, 2027 |
| Study ends | January 31, 2027 |
| Registry record updated | October 9, 2026 |
| Trial ID | NCT07867730 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18-60 with restrictive lung disease admitted to ICU and requiring invasive ventilation for more than 48 hours.
✕Probably not a fit
Patients with COPD or other obstructive diseases, unstable hemodynamics, or contraindications to the interventions may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized study investigates whether a combined program of inspiratory muscle training and positive expiratory pressure improves respiratory muscle strength and lung mechanics in mechanically ventilated patients with restrictive lung disease. It will collect physiological and clinical outcomes to see if the interventions improve lung compliance and mobilize secretions. The trial is conducted in Pakistan and follows ethical guidelines for human research. Interventions include inspiratory muscle training and conventional chest physical therapy. Participants are adults with restrictive lung disease in ICU on ventilation for more than 48 hours.
Why it matters
Potential benefit: If successful, the approach could shorten ventilation time and improve recovery by strengthening breathing muscles and aiding secretion clearance.
How similar studies have gone: Prior research suggests potential benefits of IMT and PEP, but data in ventilated RLD patients are limited, making this a relatively novel application.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged between 18 and 60 years. * Diagnosed with restrictive lung disease (RLD), including interstitial lung diseases, idiopathic pulmonary fibrosis, chest wall deformities, or neuromuscular diseases. * Admitted to the ICU and requiring invasive mechanical ventilation for more than 48 hours. * Glasgow Coma Scale score over 13, inspiratory pressures below -20 cmH2O, oxygen saturation above 90%, tidal volumes exceeding 5ml/kg, respiratory rates under 35 breaths per minute * Hemodynamically stable at the time of enrolment (as determined by the treating physician). Exclusion Criteria: * Pre-existing chronic obstructive pulmonary disease (COPD) or other primary obstructive pathologies. * Hemodynamic instability (e.g., requiring high-dose vasopressors). * Active pneumothorax or untreated bronchopleural fistula. * History of cranial or facial trauma, recent thoracic or abdominal surgery contraindicating the intervention. * Pre-existing cognitive impairment or inability to comprehend and cooperate with the training protocol.
Where it's running
-
Foundation University College of Physical Therapy Islamabad
Islamabad, Pakistan Recruiting -
Foundation University College of Physical Therapy Islamabad
Rawalpindi, Pakistan Recruiting -
Foundation University College of Physical Therapy Islamabad
Rawalpindi, Pakistan Recruiting
Study contacts
- Study coordinator: Syeda Sumaira Batool, MS-CPPT
- Email: sumaira.batool@fui.edu.pk
- Phone: +923328868680
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
SLE Registry in Pakistan to understand how lupus presents and progresses
This project is building a Pakistan lupus registry to see how SLE shows up and changes over time in adults, starting at Fauji Foundation Hospital Rawalpindi.
-
Effects of Instrument-Assisted Soft Tissue Mobilization vs Post Facilitation Stretch in Chronic Neck Pain
This trial compares two manual therapy techniques, IASTM and Post Facilitation Stretch, to see which better reduces neck pain and improves movement and function in adults with chronic neck pain.
-
Mulligan leg raise vs spinal mobilization with leg movement for lumbar radiculopathy
This trial tests whether Mulligan leg raise traction or spinal mobilization with leg movement helps people with lumbar radiculopathy feel better.
-
Flutter therapy added to chest physiotherapy after CABG in COPD patients
This study tests whether adding Flutter therapy to standard chest physiotherapy helps post-CABG patients with mild-to-moderate COPD improve breathing more than chest physiotherapy alone.
-
Coherent Breathing vs Regular Paced Breathing for COPD Dyspnea and Lung Function
In this study, adults with COPD test whether coherent breathing helps reduce shortness of breath and improve breathing tests compared with regular paced breathing.
-
Pilates breathing vs diaphragmatic breathing after PCI
This study tests whether Pilates breathing or diaphragmatic breathing helps improve oxygen levels and heart-rate variability in people who just had PCI.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.