Effects of high altitude on sleep breathing in women during their menstrual cycle
HighCycle Study: Effect of High Altitude on Sleep Disordered Breathing in Women Related to Their Menstrual Cycle Phase. A Prospective Cohort Study at 3600 m.
This study looks at how different phases of the menstrual cycle affect breathing during sleep in healthy women when they are at high altitudes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 44 Years |
| Sex | Female |
| Sponsor | University of Zurich Academic / other |
| Locations | 1 site (Bishkek, Bishkek) |
| Trial ID | NCT06498544 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how different phases of the menstrual cycle affect sleep-disordered breathing in healthy women when exposed to high altitude conditions at 3600 meters. The study will involve a cohort of women aged 18-44 who are premenopausal and have regular menstrual cycles. Participants will be monitored for changes in their sleep patterns and breathing while at high altitude, providing insights into the relationship between altitude, menstrual cycle phases, and sleep health.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy, non-smoking women aged 18-44 with regular menstrual cycles who live at lower altitudes.
Not a fit: Patients who are pregnant, nursing, or using hormonal contraceptives may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of sleep-disordered breathing in women, particularly in high-altitude environments.
How similar studies have performed: While there is limited research specifically on this topic, studies on sleep-disordered breathing and altitude have shown varying results, indicating that this approach may provide new insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Criteria: Inclusion Criteria: * Healthy, non-smoking women, age 18-44 years, without any diseases and need of regular medication (including oral contraceptives). * BMI \>18 kg/m2 and \<30 kg/m2 * Born, raised and currently living at altitudes \<1000 m * Written informed consent * Premenopausal, eumenorrheic cycle Exclusion Criteria: * Other types of contraceptives (hormonal intrauterine device, vaginal ring, subcutaneous injections or implants, among others) * Pregnancy or nursing * Anaemic (haemoglobin concentration \<10g/dl) * Any altitude trip \<4 weks before the study * Allergy to acetazolamide and other sulfonamides
Where this trial is running
Bishkek, Bishkek
- National Center for Cardiology and Internal Medicine — Bishkek, Bishkek, Kyrgyzstan (Recruiting)
Study contacts
- Study coordinator: Michael Furian, Prof. Dr.
- Email: michael.furian@usz.ch
- Phone: +41794037586
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.