Effects of green propolis extract and royal jelly on hypertension and chronic kidney disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the impact of combining green propolis extract with royal jelly on inflammation and oxidative stress in patients suffering from chronic kidney disease (CKD) and systemic arterial hypertension (SAH). Conducted as a longitudinal, randomized, double-blind, placebo-controlled trial over two months, it aims to determine the therapeutic potential of these bee products, which are rich in bioactive compounds. Participants will receive either the combination of propolis and royal jelly, royal jelly alone, or a placebo to assess the efficacy of the treatments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patients in stages 3 and 5 of CKD (GFR from 15 to 59 mL/min),
* patients receiving ambulatorial nutrition treatment at least 6 months
* patients on regular Hemodialysis treatment for at least 6 months
* patients using one to three antihypertensive drugs

Exclusion Criteria:

* autoimmune and infectious diseases,
* diabetes
* cancer
* AIDS
* pregnant women
* patients using catabolic drugs or antibiotics;
* patients with catheter access to hemodialysis;
* patients using antioxidant vitamin supplements, prebiotics, probiotics, symbiotic,
* Patients on regular intake of propolis who are allergic to corn starch or report being allergic to bee stings.
* patients with acute myocardial infarction (AMI) and/or cerebrovascular accident (CVA)

Where it's running

• Denise Mafra
  Rio de Janeiro, Rio de Janeiro, Brazil Recruiting
• Denise Mafra
  Rio de Janeiro, Rio de Janeiro, Brazil Recruiting

Study contacts

• Principal investigator: Denise Mafra, PhD — Universidade Federal Fluminense
• Study coordinator: Denise Mafra, PhD
• Email: dmafra30@gmail.com
• Phone: 5521985683003

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Streamlined renal denervation with Spyral for uncontrolled high blood pressure

  This trial will test whether a shorter, simpler renal denervation procedure using the Symplicity Spyral system can lower blood pressure in adults with uncontrolled hypertension.

  Recruiting at 20 sites Medtronic Vascular · Melbourne and 20 other locations · NCT07115953

• Gemini multi-organ denervation for uncontrolled high blood pressure

  The Gemini System is being tested to see if multi-organ denervation is safe and can lower blood pressure in adults with uncontrolled hypertension, with or without high cardiovascular risk.

  Recruiting at 18 sites Medtronic Vascular · Stanford, California and 17 other locations · NCT06907147

• Using low-dose aspirin after preeclampsia to improve recovery

  This study is testing if taking low-dose aspirin for six months after having preeclampsia can help new moms recover better by improving their blood pressure and blood vessel function.

  Recruiting Phase 4 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06281665

• Research on health inequality and genetic disparity in cardiovascular diseases

  This study is trying to understand how health differences and genetics affect heart diseases in people from various ethnic backgrounds in the UK to help improve treatments for everyone.

  Recruiting Future Genetics Limited · Wolverhampton, West Midlands · NCT03987633

• Rural Telemedicine-Enabled Care to Prevent Stroke in Older Adults in China

  A telemedicine-supported care model led by rural doctors will be tested to see if it can reduce stroke and heart problems in adults 65+ living in rural China.

  Recruiting at 2 sites Jiangsu Province (Suqian) Hospital · Suqian, Jiangsu and 1 other locations · NCT07628283

• Home-based cardiovascular health screening for people turning 50, 55, 60, 65, 70 or 75 in Uppsala

  This trial tests whether giving people a home blood pressure monitor, a dried blood spot kit, and a questionnaire can find more cardiovascular risk factors than usual care.

  Recruiting Uppsala University · Uppsala · NCT07614659

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.