Effects of Flywheel Training on Muscle Disuse
Use of Velocity Monitoring to Prescribe Appropriate Flywheel-based Inertial Training (FIT) Workloads for Exercise in Space Flight
This study tests if a special type of exercise called flywheel training can help people keep their muscle strength and balance when one leg is not used for 30 days.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 16 (estimated) |
| Ages | 35 Years to 45 Years |
| Sex | All |
| Sponsor | University of Kentucky Academic / other |
| Locations | 1 site (Lexington, Kentucky) |
| Trial ID | NCT06631053 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of flywheel-based inertial training (FIT) on muscle deconditioning caused by unilateral lower limb suspension (ULLS). Over 30 days, participants will either engage in FIT exercises or remain inactive while their left limb is unloaded. The study aims to measure changes in muscle strength, aerobic capacity, and balance regulation, using advanced imaging techniques to assess muscle function. Participants will be randomly assigned to either an exercise or control group to evaluate the effectiveness of the training regimen.
Who should consider this trial
Good fit: Ideal candidates are healthy, physically active adults who regularly engage in aerobic and resistance exercise.
Not a fit: Patients with significant health issues, such as cardiovascular or metabolic diseases, or those who do not meet the exercise criteria may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into effective rehabilitation strategies for individuals experiencing muscle atrophy and weakness due to disuse.
How similar studies have performed: Other studies have shown promising results with similar exercise interventions in preventing muscle atrophy during periods of disuse.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Regularly engaging in aerobic exercise (\> 150min/wk) and resistance exercise (\>1 time per week) for the past 12 months * Education greater than or equal to bachelor's degree (any field) Exclusion Criteria: * Waist circumference \< 55cm or \> 90cm (F) and \< 75cm or \> 100cm (M) * Body mass index \< 18.5 or \> 29.9 * Shoe size \< 25 or \>29cm. * Not regularly engaging in exercise for previous 12 months * Tobacco use within previous 6 months * Blood clotting disorder * Heart arrhythmia * Implanted device which could negatively be affected by electrical impulse or strong magnetic field such as pacemaker, internal defibrillator, or cochlear implant * Diagnosed cardiovascular, pulmonary, renal, or metabolic disease * Pregnancy (within previous 6 months) * Oral contraceptive use (within previous three months) * High resting blood pressure (\>140 systolic and/or \> 90 diastolic) * Currently or previously undergone gender-affirming therapy (hormone therapy or sexual reassignment surgery) * Low back or leg injury in previous 6 months * Currently taking medication to assist with sleep * Muscle, bone, or joint injury that limits physical activity within previous 6 months * Neurological disorder which affects balance (such as multiple sclerosis or Parkinson's disease)
Where this trial is running
Lexington, Kentucky
- University of Kentucky — Lexington, Kentucky, United States (Recruiting)
Study contacts
- Principal investigator: Lance Bollinger, PhD — University of Kentucky
- Study coordinator: Lance Bollinger, PhD
- Email: lance.bollinger@uky.edu
- Phone: 8592577904
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.