Effects of exercise regimens on bariatric patients
The POWER BARIATRIC Trial: Physical Outcomes With Exercise Regimens on BARIATRIC Patients
This study tests how different types of exercise can help severely obese people who are about to have weight loss surgery keep their muscle and lose fat, while also looking at how gut bacteria and health markers change over six months.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 20 Years to 65 Years |
| Sex | All |
| Sponsor | Tel Aviv University Academic / other |
| Locations | 1 site (Tel Aviv, Other) |
| Trial ID | NCT04777305 on ClinicalTrials.gov |
What this trial studies
This study investigates how different exercise regimens—resistance, aerobic, or a combination—affect muscle preservation and fat loss in severely obese patients after bariatric surgery. It aims to understand the role of intestinal microbiota in mediating these effects and to evaluate changes in cardiometabolic markers and physical function. Participants will be sedentary candidates for bariatric surgery and will be randomly assigned to one of the exercise groups for six months, with support from dietitians throughout the process.
Who should consider this trial
Good fit: Ideal candidates are sedentary individuals aged 18 to 65 who are preparing for primary bariatric surgery and meet specific BMI criteria.
Not a fit: Patients with severe cardiopulmonary disease, musculoskeletal impairments, cognitive impairments, or those who have had previous bariatric surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help optimize post-bariatric surgery recovery and improve overall health outcomes for patients.
How similar studies have performed: Other studies have shown promising results with exercise interventions in bariatric patients, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Sedentary participants: regular exercise performed \<1 hour per week * Candidates for primary bariatric surgery at Herzliya Medical Center in accordance to the National Institutes of Health (NIH) criteria for surgery: (body mass index (BMI) \> 40 without coexisting co-morbidities or BMI \> 35 with \> 1 severe obesity-related comorbidities) * Sex: all * Age: 18 to 65 years. Exclusion Criteria: * Severe cardiopulmonary disease (e.g., recent myocardial infarction or unstable angina) * Musculoskeletal or neuromuscular impairments that preclude exercise training * Cognitive impairments * Use of drugs that affect bone or muscle metabolism (mainly steroids) * Patients with previous bariatric surgery
Where this trial is running
Tel Aviv, Other
- Tel Aviv University — Tel Aviv, Other, Israel (Recruiting)
Study contacts
- Principal investigator: Yftach Gepner, Ph.D. — Tel Aviv University
- Study coordinator: Yftach Gepner, Ph.D.
- Email: gepner@tauex.tau.ac.il
- Phone: +972733804726
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.