Effects of exercise on nerve damage from chemotherapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase II trial investigates whether exercise can effectively treat chemotherapy-induced peripheral neuropathy (CIPN) compared to standard care. Participants with a cancer diagnosis who have experienced neurotoxic chemotherapy will be randomized into two groups: one receiving exercise interventions and the other receiving usual care. The study will assess the efficacy of exercise on CIPN symptoms through patient-reported outcomes and clinical tests. Additionally, it will explore the impact of exercise on related symptoms such as anxiety, depression, and quality of life.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Have a diagnosis of cancer
* Have received neurotoxic chemotherapy within the past nine months (could still be on chemotherapy or have already completed chemotherapy; i.e., taxane-, platinum-, vinca alkaloid-, epothilone-, or proteasome inhibitor-based chemotherapy
* Report one or more symptoms of CIPN at a level of \>= 4 on the CIPN symptom inventory on the Screening Form
* Have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1
* Have at least six months life expectancy
* Be at least 18 years of age
* Be able to read and understand English
* Be able to provide written informed consent

Exclusion Criteria:

* Have physical limitations (e.g., cardiorespiratory, orthopedic, central nervous system) that contraindicate participation in a low to moderate intensity home-based walking and progressive resistance exercise program, according to the participant's physician (e.g., oncologist, primary care) or physician's designee
* Be identified as in the active or maintenance stage of exercise behavior per the Exercise Stages of Change Question on the Screening Form
* Have planned surgery or radiation treatment during the course of the study (hormonal and biologic therapy is allowed)
* Have contraindications for MRI scanning, per the MRI safety screening procedures of the MRI facility to be utilized for this participant
* Are pregnant of have plans to become pregnant during the course of the study. Documentation of pregnancy and use of contraception can be obtained from the medical record.
* Have a current or prior cancer in the central nervous system (spine, brainstem, brain) as this would interfere with assessments of brain functional connectivity.

Where it's running

• Kaiser Permanente-Fresno
  Fresno, California, United States Recruiting
• Contra Costa Regional Medical Center
  Martinez, California, United States Recruiting
• Kaiser Permanente-Roseville
  Roseville, California, United States Recruiting
• Kaiser Permanente Downtown Commons
  Sacramento, California, United States Recruiting
• Kaiser Permanente-South Sacramento
  Sacramento, California, United States Recruiting
• Kaiser Permanente-Santa Teresa-San Jose
  San Jose, California, United States Recruiting

+43 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Principal investigator: Ian R Kleckner — University of Rochester NCORP Research Base

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Non-invasive brain stimulation to help chemotherapy-induced nerve problems in cancer survivors

  This trial tests whether a gentle brain stimulation method (tDCS) can help reduce numbness, tingling, and pain from CIPN in cancer survivors who are not currently in treatment.

  Recruiting University of Michigan Rogel Cancer Center · Ann Arbor, Michigan · NCT07673614

• Virtual LASO-3 diet program to ease chemotherapy-related numbness and tingling

  This trial tests whether a virtual diet program that lowers added sugar and increases fiber and omega-3s can help cancer survivors who have numbness, tingling, or pain after neurotoxic chemotherapy.

  Recruiting University of Michigan Rogel Cancer Center · Ann Arbor, Michigan · NCT07365007

• Video education to boost knowledge and interest in cancer clinical trials

  Adults in the Detroit area will watch a short educational video to see if it increases their knowledge about and interest in cancer clinical trials.

  Recruiting Barbara Ann Karmanos Cancer Institute · Detroit, Michigan · NCT06501040

• Using alteplase to improve fluid drainage and breathlessness in patients with malignant pleural effusion

  This study tests if the medication alteplase can help people with fluid buildup in the lungs feel better and breathe easier when regular drainage isn’t enough.

  Recruiting Early Phase 1 M.D. Anderson Cancer Center · Baltimore, Maryland and 1 other locations · NCT06184321

• Using weighted blankets to reduce anxiety in cancer patients during infusions

  This study is testing whether using weighted blankets can help reduce anxiety in cancer patients during their first infusion therapy.

  Recruiting Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT06089408

• Letermovir to prevent cytomegalovirus after pediatric stem cell transplant

  This study will try giving letermovir to CMV-positive children and adolescents receiving allogeneic stem cell transplants to see if it lowers CMV infections after transplant compared with the expected rate without prophylaxis.

  Recruiting at 32 sites Phase 3 Children's Oncology Group · Birmingham, Alabama and 32 other locations · NCT05711667

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.