Effects of exercise on heart and lung responses in post-COVID-19 patients

Acute Cardiovascular Responses to a Single Exercise Session in Patients With Post-Covid-19 Syndrome

Not applicable Interventional University of Nove de Julho · NCT06248151

This study tests how exercise affects heart and lung responses in people who have had COVID-19, comparing those with ongoing symptoms to those without.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment40 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Nove de Julho Academic / other
Locations1 site (São Paulo)
Trial IDNCT06248151 on ClinicalTrials.gov

What this trial studies

This study aims to compare the immediate cardiovascular and perceptual responses to a single exercise session in individuals who have experienced COVID-19, focusing on those with and without persistent symptoms. Participants will engage in both an exercise session, which includes aerobic and strength exercises, and a control session where they remain seated. Measurements such as blood pressure, heart rate, and oxygen saturation will be taken before, during, and after each session to assess their responses. The study employs a crossover design to ensure that each participant serves as their own control.

Who should consider this trial

Good fit: Ideal candidates include individuals who have had a positive COVID-19 test and are experiencing persistent symptoms of post-COVID-19 syndrome.

Not a fit: Patients who have not experienced COVID-19 or those with high cardiovascular risk may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could help identify effective exercise interventions for improving cardiovascular health in post-COVID-19 patients.

How similar studies have performed: While there is emerging research on post-COVID-19 rehabilitation, this specific approach to assessing acute responses to exercise in this population is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

Post-Covid Syndrome group:

* have had a positive RT-PCR test for Covid-19;
* present persistent symptoms of Post Covid 19 syndrome, which have no other health explanation according to the criteria of the World Health Organization (WHO);
* have the cognitive and physical capacity to perform the exercises; It is
* low cardiovascular risk classification according to the American College of Sports Medicine criteria.

Healthy group:

* not present persistent symptoms of Post Covid 19 syndrome, which have no other health explanation according to the criteria of the World Health Organization (WHO);
* have the cognitive and physical capacity to perform the exercises; It is
* low cardiovascular risk classification according to the American College of Sports Medicine criteria.

Where this trial is running

São Paulo

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Post-Acute COVID-19 SyndromePost-Covid 19 SyndromeCovid-19fatiguecardiovascular systemrespiratory systemrehabilitation
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.