Effects of dexmedetomidine on blood flow during laparoscopic surgery
Evaluation of the Effects of Continuous Dexmedetomidine Infusion on Systemic Microvascular Function in Patients Undergoing Laparoscopic Cholecystecthomy: a Prospective Study
This study is testing if a medication called dexmedetomidine can improve blood flow during laparoscopic surgery for adults, which might help them recover better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | National Institute of Cardiology, Laranjeiras, Brazil Government |
| Locations | 1 site (Rio de Janeiro) |
| Trial ID | NCT04946396 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of continuous intravenous infusion of dexmedetomidine on systemic microvascular function in patients undergoing laparoscopic cholecystectomy. Using a handheld device called CytoCam, researchers will visualize and measure microcirculatory perfusion in the sublingual mucosa during anesthesia. The aim is to determine whether dexmedetomidine enhances microvascular blood flow, potentially leading to improved patient outcomes during and after surgery. The study will include adult patients with specific health criteria and planned elective surgeries.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 60 with ASA physical status I or II scheduled for elective laparoscopic cholecystectomy.
Not a fit: Patients who may not benefit include those with infections, emergency surgeries, severe obesity, or autoimmune diseases.
Why it matters
Potential benefit: If successful, this approach could lead to improved microvascular function and reduced postoperative complications for patients undergoing laparoscopic surgery.
How similar studies have performed: While there have been studies on dexmedetomidine in cardiac surgery, this specific application in laparoscopic procedures is novel and not extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients of both sexes (age ≥ 18 and ≤ 60 years) * Physical state ASA I or II according to the criteria of the American Association of Anesthesiology * Planned surgery of cholecystectomy by videolaparoscopy Exclusion Criteria: * Patient's refusal to participate in the study * Inflammation or infection in the sublingual mucosa * Emergency surgery * Grade III obesity (BMI ≥39.9 kg/m2) * Pregnancy or lactation * Autoimmune diseases, malignant neoplasms
Where this trial is running
Rio de Janeiro
- Eduardo Tibiriçá — Rio de Janeiro, Brazil (Recruiting)
Study contacts
- Principal investigator: EDUARDO TIBIRICA, MD, PhD — National Institute of Cardiology
- Study coordinator: EDUARDO TIBIRICA, MD, PhD
- Email: etibi@uol.com.br
- Phone: +55-21-99914-6075
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.