Effects of Dexamethasone on Heart Function in Extremely Preterm Infants

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates how dexamethasone affects cardiac structure and performance, as well as lung water content, in infants born at less than 29 weeks of gestational age. It aims to measure changes in left ventricular hypertrophy and lung fluid retention before and after dexamethasone administration using echocardiography and lung ultrasound. The study will enroll eligible patients over a 12-month period at a single center, focusing on the hemodynamic impact of dexamethasone in this vulnerable population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* \< 29 weeks of gestational age at birth admitted at the McGill University Children Hospital's neonatal intensive care unit
* To be initiated on dexamethasone therapy for treatment of significant lung disease as per medical team decision.

Exclusion Criteria:

* Congenital heart disease (except: Atrial septum defect (ASD), Ventricular septum defect (VSD)
* Major congenital anomalies/genetic disorder (Trisomy 13, 18, 21)
* Congenital severe lung or airway malformation (Trachea-esophageal fistula, congenital pulmonary airway malformation, congenital diaphragmatic hernia)
* Twin-twin transfusion syndrome

Where it's running

• Montreal Children's hospital, Mcgill University Health Centre
  Montreal, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Gabriel Altit, MD — Montreal Children's hospital, MUHC
• Study coordinator: Gabriel Altit
• Email: gabriel.altit@mcgill.ca
• Phone: 5144124453

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Exercise ECG to tell hypertensive heart disease from obstructive CAD

  This study tests whether exercise ECG can distinguish heart problems caused by high blood pressure from those caused by obstructive coronary artery disease in patients being evaluated for chest pain.

  Recruiting University of Pisa · Pisa, PI · NCT07847463

• AI-powered ECG diagnosis and prognosis for hypertrophic cardiomyopathy

  This project will test whether artificial intelligence reading standard 12-lead ECGs can identify different types of hypertrophic cardiomyopathy and tell them apart from look‑alike heart conditions in adults.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07263204

• US benchmarking of heart and liver stiffness using shear wave ultrasound

  This project will test whether a new ultrasound device can measure heart and liver stiffness using shear wave velocity in people aged 60 or older with preserved or mildly reduced ejection fraction and left ventricular hypertrophy, with or without transthyretin amyloid cardiomyopathy, and in control subjects.

  Recruiting at 3 sites eMyosound SAS · Boston, Massachusetts and 2 other locations · NCT07215715

• Faster cardiac MRI using deep-learning image reconstruction to measure left ventricular ejection fraction

  This will test whether a faster cardiac MRI scan using deep-learning reconstruction can accurately measure ejection fraction in adults referred for left ventricular hypertrophy.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07061821

• Using echocardiograms and patient data to diagnose cardiac diseases

  This study is testing if using advanced technology to analyze heart ultrasound images along with patient information can help doctors better diagnose heart diseases.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite · NCT05942729

• Effects of a mineralocorticoid receptor antagonist on heart function in hypertensive patients

  This study is testing if a heart medication called eplerenone can improve heart function better than another medication in people with high blood pressure and thickened heart muscles.

  Recruiting Phase 4 Brigham and Women's Hospital · Boston, Massachusetts · NCT05593055

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.