Effects of Desflurane and Sevoflurane on Delirium in Older Patients
Impact of Desflurane Versus Sevoflurane Anesthesia Maintenance Methods on Incidence of Postoperative Delirium in Elderly Patients
This study tests whether using desflurane instead of sevoflurane during surgery can help older patients avoid confusion and memory problems after their procedure.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 890 (estimated) |
| Ages | 65 Years to 90 Years |
| Sex | All |
| Sponsor | West China Hospital Academic / other |
| Locations | 1 site (Chengdu, Sichuan) |
| Trial ID | NCT06176144 on ClinicalTrials.gov |
What this trial studies
This study investigates how two commonly used anesthetics, desflurane and sevoflurane, impact the occurrence of postoperative delirium and cognitive dysfunction in patients aged 65 to 90 undergoing non-cardiac or non-neurosurgical procedures. It aims to determine whether desflurane, known for its rapid recovery profile, may reduce the risk of these complications compared to sevoflurane. The study will involve patients who meet specific inclusion criteria and will assess cognitive outcomes following anesthesia. The findings could clarify the optimal anesthetic choice for elderly patients to minimize postoperative cognitive issues.
Who should consider this trial
Good fit: Ideal candidates are elderly patients aged 65 to 90 scheduled for non-cardiac or non-neurosurgical procedures requiring general anesthesia lasting two hours or more.
Not a fit: Patients with pre-existing central nervous system disorders, severe comorbidities, or those unable to communicate preoperatively may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved postoperative outcomes and quality of life for elderly patients undergoing surgery.
How similar studies have performed: Previous studies have shown mixed results regarding the effects of inhalational anesthetics on postoperative cognitive function, indicating that this area of research is still evolving.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 65 years and \< 90 years; 2. Scheduled to undergo non-cardiac or non-neurosurgery with an expected duration of 2 hours or more, under general anesthesia; 3. Agree to participate, and give signed written informed consent. Exclusion Criteria: 1. Preoperative history of schizophrenia, epilepsy, parkinsonism or any diseases of central nervous system; 2. Inability to communicate in the preoperative period (coma, dementia, language barrier, impaired hearing or vision); 3. Severe diseases in cardiovascular, respiratory, liver, kidney, or preoperative American Society of Anesthesiologists physical status classification ≥ IV; 4. Alcoholism and drug dependence; 5. Other reasons that are considered unsuitable for participation by the responsible surgeons or investigators (reasons must be recorded in the case report form).
Where this trial is running
Chengdu, Sichuan
- Department of Anesthesiology, West China Hospital — Chengdu, Sichuan, China (Recruiting)
Study contacts
- Principal investigator: Jing Yang, MD,PhD — West China Hospital
- Study coordinator: Jing Yang, MD,PhD
- Email: yangjing@wchscu.cn
- Phone: +86- 18980602269
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.