Effects of chemotherapy on male sperm DNA

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the short-term effects of chemotherapy on sperm DNA in men undergoing cancer treatment. Participants will provide semen samples before starting chemotherapy and at three time points afterward to evaluate any changes in sperm quality and genetic integrity. The study seeks to address the lack of national guidelines regarding fertility preservation for men who may not have had the opportunity to cryopreserve their sperm prior to treatment. By understanding the timing and impact of chemotherapy on male germ cells, the study hopes to provide insights into safe practices for sperm collection post-treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Be scheduled to undergo treatment with chemotherapeutic agents for a medical indication
* Be able to produce semen samples prior to chemotherapy and one week after first round of chemotherapy

Exclusion Criteria:

* Men who have previously been treated with chemotherapeutic agents.
* Men with significant oligospermia or azospermia.

Where it's running

• Magee-Womens Hospital
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Kyle Orwig, PhD — University of Pittsburgh/University of Pittsburgh Medical Center
• Study coordinator: Rachel Neelley
• Email: fertilitypreservation@upmc.edu
• Phone: 412-641-7475

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.