Effects of caffeine and sodium bicarbonate on resistance training performance

The Effect of Acute Caffeine and Sodium Bicarbonate Supplementation on Upper and Lower Submaximal Resistance Training Performance

Early Phase 1 Interventional Memorial University of Newfoundland · NCT06714331

This study is testing whether caffeine and sodium bicarbonate can help people perform better during resistance training exercises like bench presses and knee extensions.

Quick facts

PhaseEarly Phase 1
Study typeInterventional
Enrollment20 (estimated)
Ages18 Years to 40 Years
SexAll
SponsorMemorial University of Newfoundland Academic / other
Locations2 sites (St John's, Newfoundland and Labrador and 1 other locations)
Trial IDNCT06714331 on ClinicalTrials.gov

What this trial studies

This research explores how caffeine and sodium bicarbonate supplements affect short-term resistance training performance. Using a randomized, double-blind, placebo-controlled, cross-over design, the study will assess their impact on muscle activation, speed of movement, and fatigue during exercises like knee extensions and bench presses. Participants will undergo three separate visits to test the effects of each supplement compared to a placebo, measuring parameters such as peak force, movement velocity, and repetitions to failure. Blood lactate levels will also be monitored to evaluate physiological responses.

Who should consider this trial

Good fit: Ideal candidates are healthy, physically active males and females aged 18-40 with regular resistance training experience and daily caffeine intake.

Not a fit: Patients with recent musculoskeletal injuries may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance resistance training performance for athletes and fitness enthusiasts through effective supplementation.

How similar studies have performed: Previous studies have shown positive effects of caffeine on athletic performance, suggesting potential success for this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* apparently healthy, physically active males and females between 18-40 years of age with regular (minimum three times a week) resistance training experience for the last 6 months and regular caffeine intake (at least once a day).

Exclusion Criteria:

* recent musculoskeletal or musculotendinous injuries

Where this trial is running

St John's, Newfoundland and Labrador and 1 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Nutritional SupplementationResistance Trainingcaffeinesodium bicarbonatestrengthfatigueresistance training
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.