Effects of aging on exercise training responsiveness in older adults
The Role of Aging and Individual Variation in Exercise Training Responsiveness
NA · Duke University · NCT06471569
This study is testing how aging affects the way older adults respond to exercise training and whether it can improve their health, especially for those with prediabetes and heart issues.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 26 (estimated) |
| Ages | 60 Years to 90 Years |
| Sex | All |
| Sponsor | Duke University (other) |
| Locations | 1 site (Durham, North Carolina) |
| Trial ID | NCT06471569 on ClinicalTrials.gov |
What this trial studies
This study investigates how aging influences physical reserve and the body's response to exercise in older adults who have previously participated in a structured exercise program. It aims to enroll up to 8 participants for a 6-month aerobic exercise intervention, assessing various levels of exercise intensity. The focus is on understanding individual variations in exercise-induced adaptations and resilience, particularly in relation to prediabetes and cardiovascular health.
Who should consider this trial
Good fit: Ideal candidates are older adults who have previously completed the STRRIDE-PD trial and meet specific BMI and medication stability criteria.
Not a fit: Patients with insulin-dependent diabetes, significant cardiovascular issues, or other serious health conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance exercise recommendations for older adults, improving their cardiovascular health and overall physical fitness.
How similar studies have performed: Previous studies have shown promise in understanding exercise responsiveness in older adults, but this specific approach is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals who completed participation in the STRRIDE-PD trial (NCT00962962) * Body Mass Index (BMI) \> 18 and \< 45 kg/m2 * Stable dose (≥1 month) of any cardiometabolic medications Exclusion Criteria: * Poor vein access * Current use of tobacco or any nicotine products, including e-cigarettes * Insulin-dependent diabetes * Active untreated hypothyroidism with thyroid stimulating hormone (TSH) concentrations \> 10.0 uIU/mL * Systemic inflammatory or connective tissue disease, chronic infectious disease, chronic pulmonary disease or symptomatic cardiovascular disease with positive functional study by ECG or imaging * Current, actively treated malignancy other than dermatologic conditions * Absolute contraindications to exercise testing: ongoing unstable angina; uncontrolled cardiac arrhythmia with hemodynamic compromise; active endocarditis; symptomatic severe aortic stenosis; decompensated heart failure; acute pulmonary embolism, pulmonary infarction, or deep vein thrombosis; acute myocarditis or pericarditis; acute aortic dissection; physical disability that precludes safe and adequate testing * Relative contraindications to exercise testing: known obstructive left main coronary artery stenosis; moderate to severe aortic stenosis with uncertain relation to symptoms; tachyarrhythmias with uncontrolled ventricular rates; acquired advanced or complete heart block; hypertrophic obstructive cardiomyopathy with severe resting gradient; recent stroke or transient ischemic attack; mental impairment with limited ability to cooperate; uncorrected medical conditions, such as hypertension, significant anemia, important electrolyte imbalance, and hyperthyroidism * Modified testing contraindications: acute myocardial infarction (MI) within six months; resting hypertension with systolic or diastolic blood pressures \>160/90 mmHg * Unable to safely participate in an exercise program per study protocol per PI discretion * Planned, intentional weight loss during study
Where this trial is running
Durham, North Carolina
- Duke Center for Living — Durham, North Carolina, United States (RECRUITING)
Study contacts
- Principal investigator: Leanna M Ross, PhD — Duke University
- Study coordinator: Johanna L Johnson, MS
- Email: johanna.johnson@duke.edu
- Phone: 9196606766
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Prediabetic State, Cardiovascular Diseases, Insulin Resistance, Obesity, Exercise, Cardiorespiratory Fitness, Functional Capacity, Cardiometabolic Risk