Effects of a high-sodium meal on blood pressure and cardiovascular health
The Effects of a High Salt Meal on Blood Flow Regulation
This study tests how eating a high-sodium meal affects blood pressure and heart health in different racial groups, especially looking at any differences between Black and White individuals.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 19 Years to 75 Years |
| Sex | All |
| Sponsor | Indiana University Academic / other |
| Locations | 2 sites (Auburn, Alabama and 1 other locations) |
| Trial ID | NCT04244604 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the impact of a high-sodium meal on blood pressure and vascular function, particularly focusing on racial disparities between Black and White individuals. Participants will consume a meal containing up to 2500 mg of sodium, and the study aims to assess how this affects blood pressure regulation and blood vessel function. The research will also explore potential differences based on age and physical fitness, while including a diverse range of racial and ethnic groups. The findings could provide insights into the mechanisms behind salt-sensitive hypertension and cardiovascular risks associated with high sodium intake.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 19-75 with controlled blood pressure and a BMI below 35.
Not a fit: Patients with a history of cardiovascular disease, diabetes, or obesity may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved dietary recommendations and interventions for managing blood pressure and cardiovascular health, particularly in populations at higher risk.
How similar studies have performed: Previous studies have shown significant racial differences in blood pressure responses to sodium intake, suggesting this approach is grounded in established findings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Are between the ages of 19-75. 2. Have blood pressure no higher than 150/90 mmHg. 3. Have a BMI below 35 Kg/m2 (otherwise healthy) 4. Free from metabolic disease (diabetes or renal disease), pulmonary disorders (e.g., COPD \& cystic fibrosis), and cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular). 5. Do not have any precluding medical issues that prevent participants from exercising (i.e., cardiovascular issues, or muscle/joint issues including painful arthritis) or giving blood (e.g., blood thinners). 6. Are not currently smoking, using smokeless tobacco, nor smoked within the past 12 months. Exclusion Criteria: 1. High blood pressure - greater the 150/90 mmHg 2. Low blood pressure - less than 90/50 mmHg 3. History of cardiovascular disease 4. History of cancer 5. History of diabetes 6. History of kidney disease 7. Obesity (BMI \> 30 kg/m2) 8. Smoking or tobacco use 9. Current pregnancy 10. Nursing mothers 11. Communication barriers
Where this trial is running
Auburn, Alabama and 1 other locations
- Auburn University — Auburn, Alabama, United States (Completed)
- Indiana University School of Public Health — Bloomington, Indiana, United States (Recruiting)
Study contacts
- Study coordinator: Austin Robinson, PhD
- Email: ausrobin@iu.edu
- Phone: 5745141034
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.