Effects of a 12-week exercise program on the gut microbiome in older adults
The Effects of a 12-week Combined Exercise Intervention on the Gut Microbiome of Older Adults
NA · Nottingham Trent University · NCT06153719
This study tests if a 12-week exercise program can improve gut health in older adults who don't usually exercise.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 65 Years to 85 Years |
| Sex | All |
| Sponsor | Nottingham Trent University (other) |
| Locations | 1 site (Nottingham) |
| Trial ID | NCT06153719 on ClinicalTrials.gov |
What this trial studies
This study investigates how a 12-week combined exercise intervention can influence the gut microbiome of older adults aged 65-85 who are physically inactive. The research aims to understand the relationship between exercise and gut health, particularly how physical activity can improve the diversity and composition of gut microbes, which may decline with age. Participants will engage in a structured exercise program while their gut microbiome will be monitored to assess changes over the intervention period. The study seeks to provide insights into how lifestyle modifications can enhance health and wellbeing in older populations.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy, physically inactive older adults aged 65-85 with a BMI between 20-35 kg/m2.
Not a fit: Patients with significant gastrointestinal diseases, cancer, or those on certain medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could improve gut health and overall wellbeing in older adults, potentially reducing their susceptibility to various diseases.
How similar studies have performed: Other studies have shown promising results in improving gut microbiome health through exercise, suggesting this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged between 65-85 years old * Healthy, free-living individuals * Vaccinated against COVID-19 * Physically inactive (\<150 mins/week of PA) * No participation in any exercise intervention studies in the last 3 months * BMI Between 20-35 kg/m2 Exclusion Criteria: * The use of antibiotics 3 months before or during the study * Cancer * Intestinal inflammatory conditions (e.g., Crohns, ulcerative colitis) * Consumption of proton pump inhibitors (e.g., omeprazole, lansoprazole, etc...) * Auto-immune diseases * GI diseases (e.g., IBS, peptic ulcers) * Routine consumption of pre and/or probiotic foods or supplements * On blood thinners
Where this trial is running
Nottingham
- Nottingham Trent University - Clifton campus — Nottingham, United Kingdom (RECRUITING)
Study contacts
- Principal investigator: Kirsty Hunter — Nottingham Trent University
- Study coordinator: Kirsty Hunter
- Email: kirsty.hunter@ntu.ac.uk
- Phone: +44 (0)115 848 3069
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Physical Inactivity, Gut microbiome, Exercise, Physical activity, Physical inactivity, Older adults, Gut microbiota