Effect of Songling Xuemaikang Capsules on mild hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the efficacy of Songling Xuemaikang Capsules (SLXMKC) in patients with grade 1 essential hypertension. It aims to assess the capsules' impact on vascular function and structure, as well as to explore the underlying mechanisms of their therapeutic effects. Participants will receive either the SLXMKC, a lifestyle intervention, or a placebo in a randomized controlled format. The study targets individuals aged 35-65 who have not been consistently taking antihypertensive medications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 35-65 years old, male or female;
* Grade 1 essential hypertension;
* Taking no antihypertensive drugs or taking antihypertensive drugs irregularly in the past ;
* Sign the informed consent;

Exclusion Criteria:

* Significant liver and kidney dysfunction, ALT and AST upper the twice of normal range, Scr≥2.0mg/dl, eGFR\<60ml/(min·1. 73m2);
* Gastrointestinal diseases, which may affect drug absorption;
* Be allergic to the clinical trial medicine;
* Pregnant or breastfeeding women, men who plan to give birth within half a year;
* Combined with other serious primary diseases or malignant tumors;
* Hyperlipidemia with or without taking lipid-lowering drugs;
* Combined with left ventricular hypertrophy, ABI \< 0.9, CIMT ≥ 0.9mm or atherosclerotic plaque;
* Hypertensive comorbidities (cerebrovascular disease, other cardiovascular diseases, renal disease, peripheral artery disease, retinopathy, diabetes);
* Other serious conditions in which is not fit for the study.

Where it's running

• Xiyuan Hospital of China Academy of Chinese Medical Sciences
  Beijing, Beijing Municipality, China Recruiting
• Suzhou Hosptial of Traditional Chinese Medicine
  Suzhou, Jiangsu, China Not yet recruiting
• Affiliated Hospital of Shandong University of Traditional Chinese Medicine
  Jinan, Shandong, China Not yet recruiting
• China Academy of Chinese Medical Sciences Xiyuan Hospital Jining Hospital
  Jining, Shandong, China Not yet recruiting
• China Academy of Chinese Medical Sciences Xiyuan Hospital Shanxi Hospital
  Taiyuan, Shanxi, China Not yet recruiting

Study contacts

• Study coordinator: Anlu Wang, Doctor
• Email: wwanganlu@126.com
• Phone: 010-62835342

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.