Effect of oxygen during exercise in patients with chronic lung disease
Hyperoxia During Pulmonary Rehabilitation in Chronic Lung Disease - Does it Matter?
This study tests if giving extra oxygen to people with chronic lung disease while they exercise helps them feel better compared to using regular air.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Eastern Switzerland University of Applied Sciences Academic / other |
| Locations | 1 site (Winterthur, Zürich) |
| Trial ID | NCT06174207 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of supplemental oxygen on patients with chronic lung diseases during exercise. It aims to determine whether providing oxygen during a constant work rate exercise test improves outcomes compared to using sham air. The study will include 25 patients who are stable and have exercise-induced hypoxemia, defined as a drop in oxygen saturation during a walking test. Participants will undergo an incremental exercise test to assess the effects of oxygen therapy.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 with chronic lung diseases who experience a drop in oxygen saturation during exercise but have stable conditions.
Not a fit: Patients with severe resting hypoxemia or unstable conditions requiring intensive care will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the management of exercise-induced hypoxemia in patients with chronic lung diseases.
How similar studies have performed: While the effects of oxygen therapy during exercise have been explored, this specific approach is novel and not extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * We will include male and female lung disease patients undergoing pulmonary rehabilitation: aged ≥ 18 years; stable condition \> 3 weeks (e.g. no exacerbations); resting oxygen saturation (SpO2) ≥ 88% and exercise induced hypoxemia defined by a fall in SpO2 by ≥ 4% during a 6-minute walking test (6MWT); informed consent as documented by signature. Exclusion Criteria: * Severe daytime resting hypoxemia (SpO2 \< 88% or partial pressure of oxygen (PaO2) \< 8 kPa); unstable condition requiring adaptation of pharmacologic and other treatment modalities or requirement of intensive care or relevant severe concomitant disease; inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, neurological or orthopedic problems with walking disability or inability to ride a bicycle; women who are pregnant or breast feeding; enrolment in another clinical trial with active treatment.
Where this trial is running
Winterthur, Zürich
- Kantonsspital Winterthur — Winterthur, Zürich, Switzerland (Recruiting)
Study contacts
- Principal investigator: Swantje Beyer, Dr.med. — Kantonsspital Winterthur KSW
- Study coordinator: Stéphanie Saxer, PhD
- Email: stephanie.saxer@ost.ch
- Phone: +41 58 257 12 97
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.