Eating almonds before meals to help keep blood sugar steady

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 25-50 with signs of impaired glucose control will try eating almonds before meals to see if post-meal blood sugar rises are reduced. The study has two parts: a clinic phase to measure short-term responses and a home phase to observe longer-term effects while following a provided diet. Some days participants eat almonds before meals, on other days they do not, to compare outcomes. The researchers also look for which individuals seem to benefit most consistently in both settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 25-50 years
* Females over 40 years must have had a cycle in the last 6 months
* Body mass index (BMI) at least 18.5 and at most 55.0 kg/m2
* Impaired blood glucose by at least one of the following criteria:
* Fasting blood glucose at least 100 mg/dL (5.6 mmol/L) and less than 125 mg/dL (6.9 mmol/L)
* HbA1c at least 5.7% and less than 6.5%
* Willing and able to comply with study foods
* Willing and able to ingest acetaminophen as part of study procedures
* Able to read, speak, and understand English

Exclusion Criteria:

* Weight change ≥5% in past 6 months, actively trying to lose weight, or unwilling to remain weight stable throughout the study based on self-report
* Recent history within past 12 months of medical provider-diagnosed cardiovascular, renal, or liver disease that required treatment
* Current or past diagnosis of cancer (except skin cancer) in the last 5 years
* Current or past diagnosis of type 1 or type 2 diabetes
* Recent history within past 12 months of medical provider-diagnosed gastrointestinal or neurological disorders if not managed/stable for at least 3 months (with or without treatment)
* Recent history within past 12 months of medical provider-diagnosed psychiatric disorders including eating disorders or severe depression if not managed/stable for at least 3 months (with or without treatment)
* Food allergies or other reasons preventing consumption of study foods
* Any glucose-lowering medication except biguanides (e.g., Metformin) if stable for at least 3 months or incretins (i.e., GLP-1RA-based) if stable for at least 3 months
* Current smoking or vaping or history of smoking or vaping in the past 6 months
* Binge and/or heavy drinking (i.e., \>3 drinks on any given occasion and/or \>7 drinks/week)
* Currently pregnant or planning to become pregnant or breastfeed in the next 3 months by self-report

Where it's running

• Pennington Biomedical Research Center
  Baton Rouge, Louisiana, United States Recruiting

Study contacts

• Study coordinator: Kaja Falkenhain, PhD
• Email: kaja.falkenhain@pbrc.edu
• Phone: 225-763-2558

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.