Genetic predictors of weight loss with GLP-1/GIP therapies in obesity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this prospective cohort, adults starting either semaglutide or tirzepatide will have baseline clinical, biochemical, and genetic assessments and will be followed for six months to see if genetic factors help predict weight loss response. The study will analyze a Genetic Risk Score and selected SNPs to build predictive models of treatment response. It aims to improve understanding of why individuals vary in weight loss on these therapies and to guide personalized treatment decisions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* BMI ≥40 kg/m² or ≥37 kg/m² with comorbidities
* Initiation of semaglutide or tirzepatide

Exclusion Criteria:

* Prior bariatric surgery
* Secondary causes of obesity
* Active malignancy
* Chronic pancreatitis
* Family history of medullary thyroid carcinoma

Where it's running

• Laiko General Hospital, Athens
  Athens, Greece Recruiting

Study contacts

• Study coordinator: Maria P Yavropoulou, MD, MSc, PDH
• Email: myavropoulou@med.uoa.gr
• Phone: +306936159517

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.