Early warning and stratified diagnosis of postoperative respiratory failure using ventilator waveform features

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational cohort study will collect ventilator waveform data from adults who have undergone major surgery and require mechanical ventilation postoperatively. The team will analyze waveform image features to identify signals that precede postoperative respiratory failure, and to classify patients into low-, intermediate-, or high-risk groups, as well as severity levels if PRF occurs. An automated framework will be developed to extract waveform features and support early warning and risk stratification. The study is led by West China Hospital and will be conducted in Chengdu, Sichuan. Participation requires informed consent and adherence to ICU data collection protocols.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years;
* Patients receiving mechanical ventilation after surgery and transferred directly to the ICU;
* Patients expected to require or actually requiring mechanical ventilation for more than 24 hours after surgery;
* Patients or their legally authorized representatives providing written informed consent.

Exclusion Criteria:

* Respiratory failure occurring before surgery;
* Severe pulmonary disease diagnosed before surgery, including but not limited to severe chronic obstructive pulmonary disease (COPD; GOLD stage 3-4), severe interstitial lung disease (PaO₂/FiO₂ \<300 mmHg), active pneumonia, and severe pulmonary hypertension;
* Preoperative mechanical ventilation for \>48 hours;
* A decision made immediately after surgery to withhold or withdraw active treatment, including invasive mechanical ventilation;
* Expected survival of less than 48 hours;
* Inability to connect to or record the required ventilator waveform data and/or electronic medical record data;
* Other severe underlying diseases, including but not limited to end-stage liver disease, dialysis-dependent renal failure, and advanced malignancy with a short expected survival.

Where it's running

• Chi Zhang
  Chengdu, Sichuan, China Recruiting

Study contacts

• Principal investigator: Chi Zhang, Dr. — West China Hospital
• Study coordinator: Chi Zhang, Dr.
• Email: zhangchifujian@qq.com
• Phone: +86 18030758033

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.