Effect of high oxygen levels on breathing recovery after anesthesia
Official title: Recovery of Ventilation After General Anesthesia for Robotic-Assisted Laparoscopic Nephrectomy or Prostatectomy: The Effect of Oxygen Supplementation
Run by Stanford University · NCT05379673 · Data updated 2026-11-12
This study tests if giving patients more oxygen after anesthesia helps them breathe better and reduces the chance of breathing problems.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Stanford University Academic / other |
| Locations | 1 site (Stanford, California) |
| Status | Recruiting |
| Started | October 4, 2022 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | September 24, 2026 |
| Trial ID | NCT05379673 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients with ASA physical status I-III, a BMI under 40 kg/m2, and scheduled for robotic-assisted radical laparoscopic nephrectomy or prostatectomy.
✕Probably not a fit
Patients with chronic obstructive pulmonary disease (COPD) or severe comorbidities may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized-controlled trial investigates how oxygen supplementation affects breathing recovery in patients after general anesthesia. It compares two approaches: one with high oxygen levels aimed at maintaining oxygen saturation above 96% and another with conservative oxygen levels targeting saturation between 90-94%. The study will monitor patients for 90 minutes post-extubation to assess the time spent with elevated carbon dioxide levels in the blood. The goal is to determine if higher oxygen levels can improve ventilation and reduce the risk of respiratory failure.
Why it matters
Potential benefit: If successful, this approach could enhance recovery from anesthesia and reduce the incidence of postoperative respiratory complications.
How similar studies have gone: Previous studies have shown promising results with similar oxygen supplementation approaches, indicating potential for success in this confirmatory trial.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status I-III * Body mass index (BMI) less than 40 kg/m2 * Scheduled to undergo robotic-assisted radical laparoscopic nephrectomy or prostatectomy. Exclusion Criteria: * Patients with a diagnosis of chronic obstructive pulmonary disorder (COPD), severe neurological, cardiopulmonary, psychiatric, or untreated thyroid disorder * Chronic pain condition that is being treated with opioids * Patients with a hematocrit lower than 30% at the end of surgery, or those with an excessive blood loss, requiring transfusion of blood products during surgery.
Where it's running
-
Stanford University School of Medicine
Stanford, California, United States Recruiting
Study contacts
- Principal investigator: Anthony Doufas, MD, PhD — Professor, Department of Anesthesiology, Stanford University Medical School
- Study coordinator: Anthony Doufas, MD, PhD
- Email: agdoufas@stanford.edu
- Phone: 650-498-7699
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.