Early intervention for infants at risk for autism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to determine the optimal timing for intervention among infants at increased likelihood for autism due to having an older sibling with autism. Infants aged 6-8 months will be recruited and assessed before being randomized to either a monitoring condition or a coaching intervention that incorporates JASPER and Babble Bootcamp. The study will utilize a Sequential Multiple Assignment Randomized Trial (SMART) design to evaluate communication and language outcomes at 24 months based on different intervention timings. The goal is to inform clinical decision-making regarding the best time to transition to more intensive interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* This study will recruit approximately 140 infants ages 6-8 months of age who are younger siblings of children with ASD.
* Both males and females are eligible for study participation and will be recruited.
* Family income is under the very low income described under the Department of Housing and Community DevelopmentDivision of Housing Policy Agreement for the city of Los Angeles.

Exclusion Criteria:

* Infants who have seizures and are not stable on anti-seizure medication
* Infant is expected to have surgery over the next year
* Infant has associated physical disorders, and/or co-morbid with other syndromes or diseases.
* All of the children will be free of additional sensory or motor impairments (e.g., Visual or hearing impairment) and othergenetic syndromes (e.g., Down Syndrome).
* In addition, infants who are premature or less than 34 weeks (gestational age \<34 weeks) will be excluded.

Where it's running

• UCLA
  Los Angeles, California, United States Recruiting
• University of Massachusetts Medical Center
  Worcester, Massachusetts, United States Recruiting

Study contacts

• Study coordinator: Connie Kasari, PhD
• Email: kasari@gseis.ucla.edu
• Phone: 310-825-8342

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.